Peripheral tissue inflammation can alter the properties of somatic sensory pathways,
causing behavioral hypersensitivity and resulting in increased responses to pain caused by …

Pain in the head and face, which can be very severe and debilitating, often involves
activation of trigeminal ganglion nerves. The craniofacial symptoms can manifest as acute or …

While physiological pain (nociceptive pain) has a protective role in warning of potential
tissue damage in response to a variety of noxious stimuli, pathological pain (neuropathic …

Trigeminal nerve injury is known to cause severe persistent pain in the orofacial region. This
pain is difficult to diagnose and treat. Recently, many animal studies have reported that …

Background: Glial cells have been shown to directly participate to the genesis and
maintenance of chronic pain in both the sensory ganglia and the central nervous system …

Peripheral sensory ganglia contain the somata of neurons mediating mechanical, thermal,
and painful sensations from somatic, visceral, and oro‐facial organs. Each neuronal cell …

Trigeminal neuropathic pain (TGN) is an attacking, abrupt, electric-shock headache
involving abnormal cortical activity. The neural mechanism underlying TGN remains elusive …

The trigeminal sensory system is unique in its innervation of structures specific to the
orofacial area. Nociceptive trigeminal afferents are known to synapse with second-order …

Objective.—The goal of this study was to investigate neuronal–glial cell signaling in
trigeminal ganglia under basal and inflammatory conditions using an in vivo model of …

Excruciating trigeminal neuralgia (TN) management is very difficult and severely affects the
patient's quality of life. Earlier studies have shown that the trigeminal ganglion (TG) …