Interleukin 1α is critical for resistance against highly virulent Aspergillus fumigatus isolates

AK Caffrey-Carr, CH Kowalski, SR Beattie… - Infection and …, 2017 - Am Soc Microbiol
Heterogeneity among Aspergillus fumigatus isolates results in unique virulence potential
and inflammatory responses. How these isolates drive specific immune responses and how …

IL-1α Signaling Is Critical for Leukocyte Recruitment after Pulmonary Aspergillus fumigatus Challenge

AK Caffrey, MM Lehmann, JM Zickovich… - PLoS …, 2015 - journals.plos.org
Aspergillus fumigatus is a mold that causes severe pulmonary infections. Our knowledge of
how A. fumigatus growth is controlled in the respiratory tract is developing, but still limited …

Heterogeneity among isolates reveals that fitness in low oxygen correlates with Aspergillus fumigatus virulence

CH Kowalski, SR Beattie, KK Fuller, EA McGurk… - MBio, 2016 - Am Soc Microbiol
Previous work has shown that environmental and clinical isolates of Aspergillus fumigatus
represent a diverse population that occupies a variety of niches, has extensive genetic …

Isolate-Dependent Growth, Virulence, and Cell Wall Composition in the Human Pathogen Aspergillus fumigatus

N Amarsaikhan, EM O'Dea, A Tsoggerel, H Owegi… - PloS one, 2014 - journals.plos.org
The ubiquitous fungal pathogen Aspergillus fumigatus is a mediator of allergic sensitization
and invasive disease in susceptible individuals. The significant genetic and phenotypic …

Impaired interferon-γ responses, increased interleukin-17 expression, and a tumor necrosis factor–α transcriptional program in invasive aspergillosis

DPH Armstrong-James, SA Turnbull… - The Journal of …, 2009 - academic.oup.com
Background Invasive aspergillosis (IA) is the most common cause of death associated with
fungal infection in the developed world. Historically, susceptibility to IA has been associated …

Host lung environment limits Aspergillus fumigatus germination through an SskA-dependent signaling response

ME Kirkland, MK Stannard, CH Kowalski, D Mould… - Msphere, 2021 - Am Soc Microbiol
Aspergillus fumigatus isolates display significant heterogeneity in growth, virulence,
pathology, and inflammatory potential in multiple murine models of invasive aspergillosis …

The pathobiology of Aspergillus fumigatus

JP Latgé - Trends in microbiology, 2001 - cell.com
Aspergillus fumigatus is the most prevalent airborne fungal pathogen in developed
countries, and in immunocompromised patients causes a usually fatal invasive aspergillosis …

Aspergillus fumigatus, a saprotrophic pathogenic fungus

JP Latge - Mycologist, 2003 - Elsevier
Aspergillus fumigatus is the most common and life-threatening aerial fungal pathogen,
especially among immuno-compromised hosts. Understanding the pathobiology of this …

Aspergillus fumigatus morphology and dynamic host interactions

FL Van De Veerdonk, MS Gresnigt, L Romani… - Nature Reviews …, 2017 - nature.com
Aspergillus fumigatus is an environmental filamentous fungus that can cause life-threatening
disease in immunocompromised individuals. The interactions between A. fumigatus and the …

Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis

TRT Dagenais, NP Keller - Clinical microbiology reviews, 2009 - Am Soc Microbiol
Aspergillus species are globally ubiquitous saprophytes found in a variety of ecological
niches. Almost 200 species of aspergilli have been identified, less than 20 of which are …