Background Activation of extracellular signal-regulated kinase1/2 (ERK1/2) in dorsal horn of
the spinal cord by peripheral inflammation is contributed to inflammatory pain …

Background Electroacupuncture (EA) has a substantial analgesic effect on inflammatory
pain induced by complete Freund's adjuvant (CFA). The activation of the c-Jun N-terminal …

Background Previous studies have demonstrated that p38 MAPK signal transduction
pathway plays an important role in the development and maintenance of inflammatory pain …

Purpose Chemokine CX3CL1 and its receptor CX3CR1 in the lumbar spinal cord play
crucial roles in pain processing. Electroacupuncture (EA) is recognized as an alternative …

Results of our past studies showed that hippocampal muscarinic acetylcholine receptor
(mAChR)‐1 mRNA and differentially expressed proteins participating in MAPK signaling …

The therapeutic effect of electroacupuncture (EA) on inflammatory pain has been well
recognized clinically, but the mechanism is unclear. Interleukin-10 (IL-10), which is …

Background: Hyperalgesic priming (HP) is a model of the transition from acute to chronic
pain. Electroacupuncture (EA) could inhibit pain development through the peripheral dorsal …

Objective To investigate whether analgesic effect of electroacupuncture (EA) is affected by
p38 mitogen-activated protein kinase (p38 MAPK) on microglia. Methods There were two …

Growing evidence indicates that neurotrophin‐3, interleukin‐1β, and spinal glia are involved
in neuropathic pain derived from dorsal root ganglia to spinal cord. Electroacupuncture is …

Background: Evidence shows that the Janus kinase 2 (JAK2)/signal transducer and activator
of transcription 3 (STAT3) signaling pathway participates in the pathogenesis of neuropathic …