Virtually all diseases affect multiple organs. However, our knowledge of the body-wide
effects remains limited. Here, we report the body-wide transcriptome landscape across 13 …

Here, we performed a comprehensive intra-tissue and inter-tissue multilayer network
analysis of the human transcriptome. We generated an atlas of communities in gene co …

Background Genomic medicine has paved the way for identifying biomarkers and
therapeutically actionable targets for complex diseases, but is complicated by the …

Fine-mapping and gene-prioritisation techniques applied to the latest Genome-Wide
Association Study (GWAS) results have prioritised hundreds of genes as causally …

Following the publication of the complete human genomic sequence, the post-genomic era
is driven by the need to extract useful information from genomic data. Genomics …

Background Predicting molecular responses in human by extrapolating results from model
organisms requires a precise understanding of the architecture and regulation of biological …

Human diseases are inherently complex and governed by the complicated interplay of
several underlying factors. Clinical research focuses on behavioral, demographic and …

The pattern of how gene co-regulation varies across tissues determines human health.
However, inferring tissue-specific regulatory networks and associating them with human …

Genome-wide association studies provide a powerful means of identifying loci and genes
contributing to disease, but in many cases, the related cell types/states through which genes …

Prediction algorithms for protein or gene structures, including transcription factor binding
from sequence information, have been transformative in understanding gene regulation …