Glioblastomas are the most common and malignant astrocytic brain tumors in human adults.
The tumor suppressor gene TP53 is commonly mutated and/or lost in astrocytic brain tumors …

Signaling of platelet derived growth factor receptor alpha (PDGFRA) is critically involved in
the development of gliomas. However, the clinical relevance of PDGFRA expression in …

Background Deregulation of platelet-derived growth factor (PDGF) signaling is a hallmark of
malignant glioma. Two alternatively spliced PDGF-A mRNAs have been described …

Aberrant expression of the platelet‐derived growth factor α‐receptor (PDGFRA) gene has
been associated with various diseases, including neural tube defects and gliomas. We have …

We have previously shown that platelet-derived growth factor AA (PDGF-AA) stimulates the
expansion of neuronal progenitors from neural stem cells, but is unable to replace fibroblast …

Platelet-derived growth factor (PDGF) is expressed in many different tumors, but its precise
roles in tumorigenesis remain to be fully defined. Here, we report on a mouse model that …

Previously rodent preclinical research in gliomas frequently involved implantation of cell
lines such as C6 and 9L into the rat brain. More recently, mouse models have taken over …

Platelet-derived growth factor B (PDGF-B) overexpression induces gliomas of different
grades from murine embryonic neural progenitors. For the first time, we formally …

Background: Malignant gliomas are the most prevalent type of primary brain tumours but the
therapeutic armamentarium for these tumours is limited. Platelet-derived growth factor …

Background Gliomas are thought to form by clonal expansion from a single cell-of-origin,
and progression-associated mutations to occur in its progeny cells. Glioma progression is …