Emerging pharmacotherapies for alcohol use disorder
BJ Mason - Neuropharmacology, 2017 - Elsevier
The identification of different stages within the alcohol use disorder (AUD) cycle that are
linked to neurocircuitry changes in pathophysiology associated with the negative emotional …
linked to neurocircuitry changes in pathophysiology associated with the negative emotional …
Driving the downward spiral: Alcohol‐induced dysregulation of extended amygdala circuits and negative affect
Alcohol use disorder (AUD) afflicts a large number of individuals, families, and communities
globally. Affective disturbances, including stress, depression, and anxiety, are highly …
globally. Affective disturbances, including stress, depression, and anxiety, are highly …
A biological framework for emotional dysregulation in alcohol misuse: from gut to brain
Alcohol use disorder (AUD) has been associated with impairments in social and emotional
cognition that play a crucial role in the development and maintenance of addiction …
cognition that play a crucial role in the development and maintenance of addiction …
Synaptic effects of IL-1β and CRF in the central amygdala after protracted alcohol abstinence in male rhesus macaques
A major barrier to remission from an alcohol use disorder (AUD) is the continued risk of
relapse during abstinence. Assessing the neuroadaptations after chronic alcohol and …
relapse during abstinence. Assessing the neuroadaptations after chronic alcohol and …
A sustained depressive state promotes a guanfacine reversible susceptibility to alcohol seeking in rats
D Riga, LJM Schmitz, JE Van Der Harst… - …, 2014 - nature.com
High rates of comorbidity between alcohol use disorder (AUD) and major depressive
disorder (MDD) are reported. Preclinical models examining effects of primary depression on …
disorder (MDD) are reported. Preclinical models examining effects of primary depression on …
Alcohol dependence and free-choice drinking in mice
WC Griffin III - Alcohol, 2014 - Elsevier
Alcohol dependence continues to be an important health concern and animal models are
critical to furthering our understanding of this complex disease. A hallmark feature of …
critical to furthering our understanding of this complex disease. A hallmark feature of …
Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways
Clinical studies suggest that women are more likely than men to relapse to alcohol drinking
in response to stress; however, the mechanisms underlying this sex difference are not well …
in response to stress; however, the mechanisms underlying this sex difference are not well …
Alcohol to down-regulate negative and positive emotions: Extending our understanding of the functional role of alcohol in relation to posttraumatic stress disorder
Introduction Functional models of posttraumatic stress disorder (PTSD) and alcohol use
disorder (AUD) underscore the role of internally-driven negative reinforcement. However …
disorder (AUD) underscore the role of internally-driven negative reinforcement. However …
Sex differences in the synergistic effect of prior binge drinking and traumatic stress on subsequent ethanol intake and neurochemical responses in adult C57BL/6J …
DA Finn, ML Helms, MA Nipper, A Cohen, JP Jensen… - Alcohol, 2018 - Elsevier
Alcohol-use disorders (AUDs) are characterized by repeated episodes of binge drinking.
Based on reports that exposure to predator odor stress (PS) consistently increases ethanol …
Based on reports that exposure to predator odor stress (PS) consistently increases ethanol …
Assessment of affective and somatic signs of ethanol withdrawal in C57BL/6J mice using a short-term ethanol treatment
EE Perez, M De Biasi - Alcohol, 2015 - Elsevier
Alcohol is one of the most prevalent addictive substances in the world. Withdrawal
symptoms result from abrupt cessation of alcohol consumption in habitual drinkers. The …
symptoms result from abrupt cessation of alcohol consumption in habitual drinkers. The …