Emerging pharmacotherapies for alcohol use disorder

BJ Mason - Neuropharmacology, 2017 - Elsevier
The identification of different stages within the alcohol use disorder (AUD) cycle that are
linked to neurocircuitry changes in pathophysiology associated with the negative emotional …

Driving the downward spiral: Alcohol‐induced dysregulation of extended amygdala circuits and negative affect

SW Centanni, G Bedse, S Patel… - Alcoholism: Clinical …, 2019 - Wiley Online Library
Alcohol use disorder (AUD) afflicts a large number of individuals, families, and communities
globally. Affective disturbances, including stress, depression, and anxiety, are highly …

A biological framework for emotional dysregulation in alcohol misuse: from gut to brain

C Carbia, S Lannoy, P Maurage, E López-Caneda… - Molecular …, 2021 - nature.com
Alcohol use disorder (AUD) has been associated with impairments in social and emotional
cognition that play a crucial role in the development and maintenance of addiction …

Synaptic effects of IL-1β and CRF in the central amygdala after protracted alcohol abstinence in male rhesus macaques

RR Patel, FP Varodayan, MA Herman… - …, 2022 - nature.com
A major barrier to remission from an alcohol use disorder (AUD) is the continued risk of
relapse during abstinence. Assessing the neuroadaptations after chronic alcohol and …

A sustained depressive state promotes a guanfacine reversible susceptibility to alcohol seeking in rats

D Riga, LJM Schmitz, JE Van Der Harst… - …, 2014 - nature.com
High rates of comorbidity between alcohol use disorder (AUD) and major depressive
disorder (MDD) are reported. Preclinical models examining effects of primary depression on …

Alcohol dependence and free-choice drinking in mice

WC Griffin III - Alcohol, 2014 - Elsevier
Alcohol dependence continues to be an important health concern and animal models are
critical to furthering our understanding of this complex disease. A hallmark feature of …

Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways

YS Mineur, V Garcia-Rivas, MA Thomas, AR Soares… - …, 2022 - Springer
Clinical studies suggest that women are more likely than men to relapse to alcohol drinking
in response to stress; however, the mechanisms underlying this sex difference are not well …

Alcohol to down-regulate negative and positive emotions: Extending our understanding of the functional role of alcohol in relation to posttraumatic stress disorder

NH Weiss, S Goncharenko, AM Raudales, MR Schick… - Addictive …, 2021 - Elsevier
Introduction Functional models of posttraumatic stress disorder (PTSD) and alcohol use
disorder (AUD) underscore the role of internally-driven negative reinforcement. However …

Sex differences in the synergistic effect of prior binge drinking and traumatic stress on subsequent ethanol intake and neurochemical responses in adult C57BL/6J …

DA Finn, ML Helms, MA Nipper, A Cohen, JP Jensen… - Alcohol, 2018 - Elsevier
Alcohol-use disorders (AUDs) are characterized by repeated episodes of binge drinking.
Based on reports that exposure to predator odor stress (PS) consistently increases ethanol …

Assessment of affective and somatic signs of ethanol withdrawal in C57BL/6J mice using a short-term ethanol treatment

EE Perez, M De Biasi - Alcohol, 2015 - Elsevier
Alcohol is one of the most prevalent addictive substances in the world. Withdrawal
symptoms result from abrupt cessation of alcohol consumption in habitual drinkers. The …