Host defense strategies against infectious diseases are comprised of both host resistance
and disease tolerance. Resistance is the ability of the host to prevent invasion or to eliminate …

Mycobacterium tuberculosis is the most prevalent infectious pathogen in the world, largely
due to its unique interactions with the human immune system. Even in a normal host, a …

Mycobacterium tuberculosis continues to be one of the most successful pathogens on earth.
Upon inhalation of M. tuberculosis by a healthy individual, the host immune system will …

Our understanding of the host response to infections has historically focused on “resistance”
mechanisms that directly control pathogen replication. However, both pathogen effectors …

Chronic bacterial infections are caused by pathogens that persist within their hosts and
avoid clearance by the immune system. Treatment and/or detection of such pathogens is …

Host defence strategies against Mycobacterium tuberculosis (Mtb), the bacterium that
causes tuberculosis (TB), include host resistance and disease tolerance. To date, most …

The successful establishment and maintenance of a bacterial infection depend on the
pathogen's ability to subvert the host cell's defense response and successfully survive …

Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …

Tuberculosis (TB) is a complex disease, and the success of the bacterium as an intracellular
pathogen is the outcome of its close and longstanding coevolution with the mammalian host …

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …