[HTML][HTML] Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy
Chronic kidney disease (CKD) is a worldwide public health threat that increases risk of
death due to cardiovascular complications, including left ventricular hypertrophy (LVH) …
death due to cardiovascular complications, including left ventricular hypertrophy (LVH) …
[HTML][HTML] FGF23/FGFR4-mediated left ventricular hypertrophy is reversible
Fibroblast growth factor (FGF) 23 is a phosphaturic hormone that directly targets cardiac
myocytes via FGF receptor (FGFR) 4 thereby inducing hypertrophic myocyte growth and the …
myocytes via FGF receptor (FGFR) 4 thereby inducing hypertrophic myocyte growth and the …
[HTML][HTML] FGF23 induces left ventricular hypertrophy
Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to
cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of …
cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of …
Treatment of established left ventricular hypertrophy with fibroblast growth factor receptor blockade in an animal model of CKD
GS Di Marco, S Reuter, D Kentrup… - Nephrology Dialysis …, 2014 - academic.oup.com
Background Activation of fibroblast growth factor receptor (FGFR)-dependent signalling by
FGF23 may contribute to the complex pathogenesis of left ventricular hypertrophy (LVH) in …
FGF23 may contribute to the complex pathogenesis of left ventricular hypertrophy (LVH) in …
Induction of cardiac FGF23/FGFR4 expression is associated with left ventricular hypertrophy in patients with chronic kidney disease
M Leifheit-Nestler, R große Siemer… - Nephrology Dialysis …, 2016 - academic.oup.com
Background In chronic kidney disease (CKD), serum concentrations of fibroblast growth
factor 23 (FGF23) increase progressively as glomerular filtration rate declines, while renal …
factor 23 (FGF23) increase progressively as glomerular filtration rate declines, while renal …
[HTML][HTML] Update on fibroblast growth factor 23 in chronic kidney disease
M Wolf - Kidney international, 2012 - Elsevier
Chronic kidney disease (CKD) is a public health epidemic that affects millions of people
worldwide. Presence of CKD predisposes individuals to high risks of end-stage renal …
worldwide. Presence of CKD predisposes individuals to high risks of end-stage renal …
FGF23 induced left ventricular hypertrophy mediated by FGFR4 signaling in the myocardium is attenuated by soluble Klotho in mice
There is controversy regarding whether excess FGF23 causes left ventricular hypertrophy
(LVH) directly through activation of fibroblast growth factor receptor 4 (FGFR4) in …
(LVH) directly through activation of fibroblast growth factor receptor 4 (FGFR4) in …
[HTML][HTML] Paracrine effects of FGF23 on the heart
M Leifheit-Nestler, D Haffner - Frontiers in endocrinology, 2018 - frontiersin.org
Fibroblast growth factor (FGF) 23 is a phosphaturic hormone primarily secreted by
osteocytes to maintain phosphate and mineral homeostasis. In patients with and without …
osteocytes to maintain phosphate and mineral homeostasis. In patients with and without …
Biological activities of fibroblast growth factor-2 in the adult myocardium
Abstract Fibroblast growth factor-2 (FGF-2) is a potent regulator of many cellular functions
and phenomena, including cell proliferation, differentiation, survival, adhesion, migration …
and phenomena, including cell proliferation, differentiation, survival, adhesion, migration …
Cardiac actions of fibroblast growth factor 23
C Faul - Bone, 2017 - Elsevier
Fibroblast growth factors (FGF) are mitogenic signal mediators that induce cell proliferation
and survival. Although cardiac myocytes are post-mitotic, they have been shown to be able …
and survival. Although cardiac myocytes are post-mitotic, they have been shown to be able …