[HTML][HTML] Down-regulation of CXXC5 de-represses MYCL1 to promote hepatic stellate cell activation
X Wu, W Dong, M Kong, H Ren, J Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Liver fibrosis is mediated by myofibroblasts, a specialized cell type involved in wound
healing and extracellular matrix production. Hepatic stellate cells (HSC) are the major …
healing and extracellular matrix production. Hepatic stellate cells (HSC) are the major …
[HTML][HTML] Inhibition of canonical WNT signaling pathway by β-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12
BÖ Akcora, G Storm, R Bansal - … et Biophysica Acta (BBA)-Molecular Basis …, 2018 - Elsevier
Quiescent hepatic stellate cells (HSCs), in response to liver injury, undergo characteristic
morphological transformation into proliferative, contractile and ECM-producing …
morphological transformation into proliferative, contractile and ECM-producing …
[PDF][PDF] Single‐cell transcriptomic analysis reveals a hepatic stellate cell–activation roadmap and myofibroblast origin during liver fibrosis in mice
WU Yang, H He, T Wang, N Su, F Zhang, K Jiang… - …, 2021 - Wiley Online Library
Background and Aims HSCs and portal fibroblasts (PFs) are the major sources of collagen‐
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …
Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells and protects against liver fibrosis
K Du, SH Oh, T Sun, WH Yang, JTA Chi, AM Diehl - bioRxiv, 2019 - biorxiv.org
Abstract Background and Aims Liver fibrosis develops in the context of excessive oxidative
stress, cell death and accumulation of myofibroblasts (MFs) derived from hepatic stellate …
stress, cell death and accumulation of myofibroblasts (MFs) derived from hepatic stellate …
[HTML][HTML] Disruption of myofibroblastic Notch signaling attenuates liver fibrosis by modulating fibrosis progression and regression
Z Yue, Z Jiang, B Ruan, J Duan, P Song… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
The phenotypic transformation of hepatic myofibroblasts (MFs) is involved in the whole
process of the progression and regression of liver fibrosis. Notch signaling has been …
process of the progression and regression of liver fibrosis. Notch signaling has been …
[HTML][HTML] Heterogeneity of hepatic stellate cells in fibrogenesis of the liver: insights from single-cell transcriptomic analysis in liver injury
W Zhang, SJ Conway, Y Liu, P Snider, H Chen, H Gao… - Cells, 2021 - mdpi.com
Background & Aims: Liver fibrosis is a pathological healing process resulting from hepatic
stellate cell (HSC) activation and the generation of myofibroblasts from activated HSCs. The …
stellate cell (HSC) activation and the generation of myofibroblasts from activated HSCs. The …
[HTML][HTML] MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization
J Zhang, Y Liu, H Chen, Q Yuan, J Wang, M Niu… - Cell Death & …, 2022 - nature.com
During liver fibrosis, quiescent HSCs (qHSCs) are activated to become activated HSCs
(aHSCs)/myofibroblasts. The signal adapter MyD88, an essential component of TLR …
(aHSCs)/myofibroblasts. The signal adapter MyD88, an essential component of TLR …
Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury
K Du, SH Oh, RK Dutta, T Sun, WH Yang… - Liver …, 2021 - Wiley Online Library
Abstract Background & Aims The outcome of liver injury is dictated by factors that control the
accumulation of myofibroblastic (activated) hepatic stellate cells (MF‐HSCs) but therapies …
accumulation of myofibroblastic (activated) hepatic stellate cells (MF‐HSCs) but therapies …
[HTML][HTML] FOXC2-AS1/FOXC2 axis mediates matrix stiffness-induced trans-differentiation of hepatic stellate cells into fibrosis-promoting myofibroblasts
L Sun, Y Li, H Wang, X Xiao, X Luo… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Matrix stiffness is a central modulator of hepatic stellate cells (HSCs) activation and hepatic
fibrogenesis. However, the long non-coding RNAs (lncRNAs)-regulated transcriptional …
fibrogenesis. However, the long non-coding RNAs (lncRNAs)-regulated transcriptional …
[HTML][HTML] The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis
R Bansal, J Van Baarlen, G Storm, J Prakash - Scientific reports, 2015 - nature.com
Hepatic stellate cells (HSCs) known as “master producers” and macrophages as “master
regulators”, are the key cell types that strongly contribute to the progression of liver fibrosis …
regulators”, are the key cell types that strongly contribute to the progression of liver fibrosis …