Background The benefits of blood pressure lowering treatment for prevention of
cardiovascular disease are well established. However, the extent to which these effects …

Background The effects of pharmacological blood pressure lowering at normal or high-
normal blood pressure ranges in people with or without pre-existing cardiovascular disease …

Background The benefits of reducing blood pressure are well established, but there remains
uncertainty about whether the magnitude of the effect varies with the initial blood pressure …

Importance High blood pressure (BP) is the most important risk factor for death and
cardiovascular disease (CVD) worldwide. The optimal cutoff for treatment of high BP is …

Background Recent hypertension guidelines have reversed previous recommendations for
lower blood pressure targets in high-risk patients, such as those with cardiovascular …

Background We aimed to investigate whether the benefits of blood pressure-lowering drugs
are proportional to baseline cardiovascular risk, to establish whether absolute risk could be …

Abstract Purpose of Review To review the recent large-scale randomised evidence on
pharmacologic reduction in blood pressure for the primary and secondary prevention of …

Background: Randomized controlled trials (RCTs) of blood pressure (BP) lowering lend
themselves to be meta-analyzed to help providing evidence-based recommendations for …

Hypertension has not always been recognized as a harbinger of cardiovascular
complications and premature death. Only 70 years ago, hypertension was considered the …

Objectives To determine the quantitative efficacy of different classes of blood pressure
lowering drugs in preventing coronary heart disease (CHD) and stroke, and who should …