Importance Psilocybin shows promise as a treatment for major depressive disorder (MDD).
Objective To evaluate the magnitude, timing, and durability of antidepressant effects and …

Background Psilocybin has been suggested as a novel, rapid-acting treatment for
depression. Two consecutive doses have been shown to markedly decrease symptom …

Background: Preliminary data suggest that psilocybin-assisted treatment produces
substantial and rapid antidepressant effects in patients with major depressive disorder …

The aim of this review was to determine the effect of psilocybin on depressive symptoms in
patients diagnosed with life-threatening illnesses or major depressive disorder. Systematic …

Psilocybin is increasingly studied for its antidepressant effect, but its optimal dosage for
depression remains unclear. We conducted a systematic review and a dose-response meta …

Importance Major depressive disorder (MDD) is a substantial public health burden, but
current treatments have limited effectiveness and adherence. Recent evidence suggests that …

Background Psilocybin is being studied for use in treatment-resistant depression. Methods
In this phase 2 double-blind trial, we randomly assigned adults with treatment-resistant …

Background Psilocybin is a serotonin receptor agonist that occurs naturally in some
mushroom species. Recent studies have assessed the therapeutic potential of psilocybin for …

Background Previous studies have shown that psilocybin has antidepressant effects. In the
current study, we aim to explore the dose effects of psilocybin on primary (major depression …

Importance Bipolar II disorder (BDII) is a debilitating condition frequently associated with
difficult-to-treat depressive episodes. Psilocybin has evidence for rapid-acting …