[HTML][HTML] Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans

AJ Saykin, L Shen, X Yao, S Kim, K Nho… - Alzheimer's & …, 2015 - Elsevier
Introduction Genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) have
been crucial in advancing the understanding of Alzheimer's disease (AD) pathophysiology …

[HTML][HTML] Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers

L Shen, PM Thompson, SG Potkin, L Bertram… - Brain imaging and …, 2014 - Springer
Abstract The Genetics Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI),
formally established in 2009, aims to provide resources and facilitate research related to …

[HTML][HTML] The complex genetic architecture of Alzheimer's disease: novel insights and future directions

SJ Andrews, AE Renton, B Fulton-Howard… - …, 2023 - thelancet.com
Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …

Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease

AM Fagan, C Xiong, MS Jasielec, RJ Bateman… - Science translational …, 2014 - science.org
Clinicopathological evidence suggests that the pathology of Alzheimer's disease (AD)
begins many years before the appearance of cognitive symptoms. Biomarkers are required …

The Alzheimer's disease neuroimaging initiative 2 biomarker core: a review of progress and plans

JH Kang, M Korecka, MJ Figurski, JB Toledo… - Alzheimer's & …, 2015 - Elsevier
Abstract Introduction We describe Alzheimer's Disease Neuroimaging Initiative (ADNI)
Biomarker Core progress including: the Biobank; cerebrospinal fluid (CSF) amyloid beta (Aβ …

Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans

AJ Saykin, L Shen, TM Foroud, SG Potkin… - Alzheimer's & …, 2010 - Elsevier
The role of the Alzheimer's Disease Neuroimaging Initiative Genetics Core is to facilitate the
investigation of genetic influences on disease onset and trajectory as reflected in structural …

[HTML][HTML] Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease

SG Potkin, G Guffanti, A Lakatos, JA Turner, F Kruggel… - PloS one, 2009 - journals.plos.org
Background With the exception of APOE ε4 allele, the common genetic risk factors for
sporadic Alzheimer's Disease (AD) are unknown. Methods and Findings We completed a …

[HTML][HTML] Developing an international network for Alzheimer research: the Dominantly Inherited Alzheimer Network

JC Morris, PS Aisen, RJ Bateman… - Clinical …, 2012 - ncbi.nlm.nih.gov
Abstract The Dominantly Inherited Alzheimer Network (DIAN) is a collaborative effort of
international Alzheimer disease (AD) centers that are conducting a multifaceted prospective …

Genetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunities

C Reitz - Expert review of molecular diagnostics, 2015 - Taylor & Francis
Alzheimer's disease (AD), the most common form of dementia in western societies, is a
pathologically and clinically heterogeneous disease with a strong genetic component. The …

Genomic variants, genes, and pathways of Alzheimer's disease: An overview

AC Naj, GD Schellenberg… - American Journal of …, 2017 - Wiley Online Library
Alzheimer's disease (AD)(MIM: 104300) is a highly heritable disease with great complexity
in its genetic contributors, and represents the most common form of dementia. With the …