[HTML][HTML] Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans
Introduction Genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) have
been crucial in advancing the understanding of Alzheimer's disease (AD) pathophysiology …
been crucial in advancing the understanding of Alzheimer's disease (AD) pathophysiology …
[HTML][HTML] Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers
Abstract The Genetics Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI),
formally established in 2009, aims to provide resources and facilitate research related to …
formally established in 2009, aims to provide resources and facilitate research related to …
[HTML][HTML] The complex genetic architecture of Alzheimer's disease: novel insights and future directions
SJ Andrews, AE Renton, B Fulton-Howard… - …, 2023 - thelancet.com
Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …
disorder and the most common form of dementia. AD is highly heritable, with heritability …
Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease
AM Fagan, C Xiong, MS Jasielec, RJ Bateman… - Science translational …, 2014 - science.org
Clinicopathological evidence suggests that the pathology of Alzheimer's disease (AD)
begins many years before the appearance of cognitive symptoms. Biomarkers are required …
begins many years before the appearance of cognitive symptoms. Biomarkers are required …
The Alzheimer's disease neuroimaging initiative 2 biomarker core: a review of progress and plans
Abstract Introduction We describe Alzheimer's Disease Neuroimaging Initiative (ADNI)
Biomarker Core progress including: the Biobank; cerebrospinal fluid (CSF) amyloid beta (Aβ …
Biomarker Core progress including: the Biobank; cerebrospinal fluid (CSF) amyloid beta (Aβ …
Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans
The role of the Alzheimer's Disease Neuroimaging Initiative Genetics Core is to facilitate the
investigation of genetic influences on disease onset and trajectory as reflected in structural …
investigation of genetic influences on disease onset and trajectory as reflected in structural …
[HTML][HTML] Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease
Background With the exception of APOE ε4 allele, the common genetic risk factors for
sporadic Alzheimer's Disease (AD) are unknown. Methods and Findings We completed a …
sporadic Alzheimer's Disease (AD) are unknown. Methods and Findings We completed a …
[HTML][HTML] Developing an international network for Alzheimer research: the Dominantly Inherited Alzheimer Network
JC Morris, PS Aisen, RJ Bateman… - Clinical …, 2012 - ncbi.nlm.nih.gov
Abstract The Dominantly Inherited Alzheimer Network (DIAN) is a collaborative effort of
international Alzheimer disease (AD) centers that are conducting a multifaceted prospective …
international Alzheimer disease (AD) centers that are conducting a multifaceted prospective …
Genetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunities
C Reitz - Expert review of molecular diagnostics, 2015 - Taylor & Francis
Alzheimer's disease (AD), the most common form of dementia in western societies, is a
pathologically and clinically heterogeneous disease with a strong genetic component. The …
pathologically and clinically heterogeneous disease with a strong genetic component. The …
Genomic variants, genes, and pathways of Alzheimer's disease: An overview
AC Naj, GD Schellenberg… - American Journal of …, 2017 - Wiley Online Library
Alzheimer's disease (AD)(MIM: 104300) is a highly heritable disease with great complexity
in its genetic contributors, and represents the most common form of dementia. With the …
in its genetic contributors, and represents the most common form of dementia. With the …