Assessment of minocycline and polymyxin B combination against Acinetobacter baumannii

DR Bowers, H Cao, J Zhou, KR Ledesma… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Antimicrobial resistance among Acinetobacter baumannii is increasing worldwide, often
necessitating combination therapy. The clinical utility of using minocycline with polymyxin B …

In Vivo and In Vitro Efficacy of Minocycline-Based Combination Therapy for Minocycline-Resistant Acinetobacter baumannii

YS Yang, Y Lee, KC Tseng, WC Huang… - Antimicrobial agents …, 2016 - Am Soc Microbiol
Minocycline-based combination therapy has been suggested to be a possible choice for the
treatment of infections caused by minocycline-susceptible Acinetobacter baumannii, but its …

Pharmacokinetics and pharmacodynamics of minocycline against Acinetobacter baumannii in a neutropenic murine pneumonia model

J Zhou, KR Ledesma, KT Chang… - Antimicrobial Agents …, 2017 - Am Soc Microbiol
Multidrug-resistant (MDR) Acinetobacter baumannii is increasingly more prevalent in
nosocomial infections. Although in vitro susceptibility of A. baumannii to minocycline is …

Minocycline alone and in combination with polymyxin B, meropenem, and sulbactam against carbapenem-susceptible and-resistant Acinetobacter baumannii in an in …

M Beganovic, KE Daffinee, MK Luther… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
Acinetobacter baumannii is recognized as an urgent public health threat by the Centers for
Disease Control and Prevention (CDC). Current treatment options are scarce, particularly …

Update on Acinetobacter Species: Mechanisms of Antimicrobial Resistance and Contemporary In Vitro Activity of Minocycline and Other Treatment Options

M Castanheira, RE Mendes… - Clinical infectious …, 2014 - academic.oup.com
Among Acinetobacter species, A. baumannii and other closely related species are
commonly implicated in nosocomial infections. These organisms are usually multidrug …

In vitro effect of minocycline and colistin combinations on imipenem-resistant Acinetobacter baumannii clinical isolates

TY Tan, LSY Ng, E Tan, G Huang - Journal of antimicrobial …, 2007 - academic.oup.com
Objectives The study investigated the effect of colistin and minocycline when tested singly
and in combination against Acinetobacter baumannii. Methods Thirteen unrelated imipenem …

Minocycline for the Treatment of Multidrug and Extensively Drug-Resistant A. baumannii: A Review

JN Lashinsky, O Henig, JM Pogue, KS Kaye - Infectious diseases and …, 2017 - Springer
Acinetobacter baumannii can cause life-threatening nosocomial infections associated with
high rates of morbidity and mortality. In recent years, the increasing number of infections due …

In Vitro Pharmacodynamics of Polymyxin B and Tigecycline Alone and in Combination against Carbapenem-Resistant Acinetobacter baumannii

M Hagihara, ST Housman, DP Nicolau… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Carbapenem-resistant Acinetobacter baumannii is increasing in prevalence. Polymyxin B
and tigecycline are among the most active antibiotics used against this pathogen in vitro …

Pharmacodynamics of Minocycline against Acinetobacter baumannii in a Rat Pneumonia Model

Z Tarazi, M Sabet, MN Dudley… - Antimicrobial Agents and …, 2019 - Am Soc Microbiol
Minocycline is currently approved in the United States for the treatment of infections caused
by susceptible isolates of Acinetobacter spp. The objective of these studies was to determine …

Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii

GG Rao, NS Ly, J Diep, A Forrest, JB Bulitta… - International journal of …, 2016 - Elsevier
The prevalence of heteroresistant Acinetobacter baumannii is increasing. Infections due to
these resistant pathogens pose a global treatment challenge. Here, the pharmacodynamic …