Obesity, inflammation, and postmenopausal breast cancer: therapeutic implications

A Macciò, C Madeddu - The Scientific World Journal, 2011 - Wiley Online Library
Breast cancer is the female malignant neoplasia with the highest incidence in the
industrialized world. Although early diagnosis has contributed to therapeutic success, breast …

Metabolic pathways in obesity-related breast cancer

KA Brown - Nature Reviews Endocrinology, 2021 - nature.com
This Review focuses on the mechanistic evidence for a link between obesity, dysregulated
cellular metabolism and breast cancer. Strong evidence now links obesity with the …

Obesity associated alterations in the biology of adipose stem cells mediate enhanced tumorigenesis by estrogen dependent pathways

AL Strong, TA Strong, LV Rhodes, JA Semon… - Breast Cancer …, 2013 - Springer
Introduction Obesity has been associated with increased incidence and mortality of breast
cancer. While the precise correlation between obesity and breast cancer remains to be …

Obesity and inflammation: new insights into breast cancer development and progression

NM Iyengar, CA Hudis, AJ Dannenberg - American Society of Clinical …, 2013 - ascopubs.org
The importance of inflammation in promoting carcinogenesis and tumor progression is well
recognized. Chronic inflammation caused by a variety of infectious agents can lead to the …

Obesity and breast cancer: molecular interconnections and potential clinical applications

V Simone, M D'avenia, A Argentiero, C Felici… - The …, 2016 - academic.oup.com
Obesity is an important risk factor for breast cancer (BC) in postmenopausal women;
interlinked molecular mechanisms might be involved in the pathogenesis. Increased levels …

Updated clinical evidence on the role of adipokines and breast cancer: a review

GI Verras, L Tchabashvili, DD Chlorogiannis, F Mulita… - Cancers, 2023 - mdpi.com
Simple Summary Breast cancer is currently one of the most common types of cancer and the
number one cause of cancer-related deaths in women worldwide. Despite significant …

The impact of obesity and adipokines on breast and gynecologic malignancies

S Tewari, R Vargas, O Reizes - … of the New York Academy of …, 2022 - Wiley Online Library
The link between obesity and multiple disease comorbidities is well established. In 2003,
Calle and colleagues presented the relationship between obesity and several cancer types …

Multifaceted breast cancer: the molecular connection with obesity

A Feola, S Ricci, S Kouidhi, A Rizzo… - Journal of Cellular …, 2017 - Wiley Online Library
Obesity is characterized by a disruption in energy balance regulation that results in an
excess accumulation of body fat. Its increasing prevalence poses a major public health …

The effects of adipocytes on the regulation of breast cancer in the tumor microenvironment: an update

DT Chu, T Nguyen Thi Phuong, NLB Tien, DK Tran… - Cells, 2019 - mdpi.com
Obesity is a global pandemic and it is well evident that obesity is associated with the
development of many disorders including many cancer types. Breast cancer is one of that …

Obesity and breast cancer: current insights on the role of fatty acids and lipid metabolism in promoting breast cancer growth and progression

C Blücher, SC Stadler - Frontiers in endocrinology, 2017 - frontiersin.org
Obesity and excess accumulation of adipose tissue are known risk factors for several types
of cancer, including breast cancer. With the incidence of obesity constantly rising worldwide …