Current landscape: the mechanism and therapeutic impact of obesity for breast cancer

C Zhao, W Hu, Y Xu, D Wang, Y Wang, W Lv… - Frontiers in …, 2021 - frontiersin.org
Obesity is defined as a chronic disease induced by an imbalance of energy homeostasis.
Obesity is a widespread health problem with increasing prevalence worldwide. Breast …

The many faces of obesity and its influence on breast cancer risk

T Agurs-Collins, SA Ross, BK Dunn - Frontiers in oncology, 2019 - frontiersin.org
Obesity is associated with increased risk of breast and other cancers. However, the
complexity of the underlying mechanisms, together with the interplay of diet and physical …

Local biomarkers involved in the interplay between obesity and breast cancer

JB Holm, AH Rosendahl, S Borgquist - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer is the second most common cancer in women worldwide.
The risk of developing breast cancer depends on various mechanisms, such as age …

Obesity and breast cancer prognosis: weight of the evidence

FA Sinicrope, AJ Dannenberg - Journal of clinical oncology, 2011 - ascopubs.org
The percentage of overweight and obese adults and children has been steadily increasing
during the last two decades, and it is estimated that one third of US adults are obese. 1 …

Adipose tissue as target organ in the treatment of hormone‐dependent breast cancer: new therapeutic perspectives

A Maccio, C Madeddu, G Mantovani - obesity reviews, 2009 - Wiley Online Library
Breast cancer is the female malignant neoplasia with the highest incidence in the
industrialized world. Despite many undeniable therapeutic successes obtained, breast …

[HTML][HTML] The tumor promotional role of adipocytes in the breast cancer microenvironment and macroenvironment

JJ Bernard, EA Wellberg - The American journal of pathology, 2021 - Elsevier
The role of the adipocyte in the tumor microenvironment has received significant attention as
a critical mediator of the obesity-cancer relationship. Current estimates indicate that 650 …

Adiposity, type 2 diabetes and the metabolic syndrome in breast cancer

L Vona‐Davis, M Howard‐McNatt, DP Rose - Obesity Reviews, 2007 - Wiley Online Library
Upper body obesity and the related metabolic disorder type 2 diabetes have been identified
as risk factors for breast cancer, and associated with late‐stage disease and a poor …

Angiogenesis, adipokines and breast cancer

L Vona-Davis, DP Rose - Cytokine & growth factor reviews, 2009 - Elsevier
The prevalence of overweight and obesity is rapidly increasing world wide. Numerous
epidemiological studies have shown that obesity is a risk factor for postmenopausal breast …

Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor–positive breast cancer

E Fuentes-Mattei, G Velazquez-Torres… - JNCI: Journal of the …, 2014 - academic.oup.com
Background Obesity increases the risk of cancer death among postmenopausal women with
estrogen receptor–positive (ER+) breast cancer, but the direct evidence for the mechanisms …

Leptin and adiponectin: emerging therapeutic targets in breast cancer

E Surmacz - Journal of mammary gland biology and neoplasia, 2013 - Springer
Obesity is a recognized risk factor for breast cancer development and poorer response to
therapy. Two major fat tissue-derived adipokines, leptin and adiponectin have been …