Obesity rates are climbing, representing a confounding and contributing factor to many
disease states, including cancer. With respect to breast cancer, obesity plays a prominent …

The rates of obesity and diabetes are increasing worldwide, whereas the age of onset for
both obesity and diabetes are decreasing steadily. Obesity and diabetes are associated with …

The past two decades have seen a drastic increase in obesity rates in Western societies and
emerging countries. As such, it has become increasingly important to understand the …

Obesity has a noteworthy role in breast tumor initiation and progression. Among the
mechanisms proposed, the most validated is the development of chronic low-grade …

The increasing rate of obesity worldwide is predicted to be associated with a surge in
diseases. Notably, obesity has been linked to approximately 20% of cancer cases in the …

Breast cancer progression is highly dependent on the heterotypic interaction between tumor
cells and stromal cells of the tumor microenvironment. Cancer-associated adipocytes …

Highlights•Obesity is a pandemic condition associated with both risk and prognosis of breast
cancer.•The adipokine leptin is a plausible molecular link between obesity and breast …

Background Obesity is a risk factor for breast cancer in postmenopausal women and is
associated with decreased survival and less favorable clinical characteristics such as …

Context Breast cancer is increasing in prevalence in parallel with rising rates of obesity
worldwide. Obesity is recognized as a leading modifiable risk factor for the development of …

Abstract Purpose of Review Adipocytes have adapted to store energy in the form of lipid and
also secrete circulating factors called adipokines that signal to other tissues to coordinate …