After decades of halting progress, recent large genome-wide association studies (GWAS)
are finally shining light on the genetic architecture of schizophrenia. The picture emerging is …

This article reviews recent genome-wide association studies (GWAS) of schizophrenia and
considers future research directions. Until recently, genome-wide scans for dis-ease risk …

Abstract Purpose of Review This is an era where we have significantly advanced the
understanding of the genetic architecture of schizophrenia. In this review, we consider how …

The heritability of schizophrenia is well established, and has motivated the search for
genetic variation that contributes to susceptibility. Recent progress from both genome-wide …

Highlights•Schizophrenia is highly polygenic with much missing heritability.•New statistical
tools are tailored to polygenic investigation of GWAS data.•Extensive enrichment is present …

Genome-wide association studies (GWAS) have proved to be a powerful approach for gene
discovery in schizophrenia; their findings have important implications not just for our …

Identifying the genetic underpinnings of complex diseases offers insight into the etiological
mechanisms leading to manifestation of the disease. New and more effective treatments for …

Schizophrenia is a devastating mental disorder. The level of risk in the general population is
sustained by the persistence of social, environmental and biological factors, as well as their …

Genetic research targeting schizophrenia has undergone tremendous development during
recent years. Supported by recently developed high-throughput genotyping technologies …

After two decades of frustration, genetic studies of schizophrenia have entered an era of
spectacular success. Advances in genotyping technologies and high throughput …