The genetic basis of schizophrenia has been a hotly debated research topic for decades, yet
recent studies, especially in the past year, have confirmed genetics as the major cause of …

Genome-wide association studies (GWAS) have identified a large number of gene variants
associated with schizophrenia, but these variants explain only a small portion of the …

The new GWAS from the Schizophrenia Working Group of the Psychiatric Genomics
Consortium (2014) clearly validates a genetic approach to understanding schizophrenia …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

Though clinically useful, the diagnostic systems currently employed are not well equipped to
capture the substantial clinical heterogeneity observed for most psychiatric disorders, as …

On the basis of recent data from candidate region/gene and genome-wide association
studies (GWAS) and their follow-up investigations, the number of genes potentially …

Over 100 loci are now associated with schizophrenia risk as identified by single nucleotide
polymorphisms (SNPs) in genome-wide association studies. These findings mean that …

Genetic epidemiological studies strongly suggest that additive and interactive genes, each
with small effects, mediate the genetic vulnerability for schizophrenia. With the human …

Determining the causes of schizophrenia has been a notoriously intractable problem,
resistant to a multitude of investigative approaches over centuries. In recent decades …

Genetic architecture of a disease comprises the number, frequency, and effect sizes of
genetic risk alleles and the way in which they combine together. Before the genomic …