What genes are differentially expressed in individuals with schizophrenia? A systematic review

AK Merikangas, M Shelly, A Knighton, N Kotler… - Molecular …, 2022 - nature.com
Schizophrenia is a severe, complex mental disorder characterized by a combination of
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …

Evaluation of risk loci for schizophrenia derived from genome‐wide association studies in a German population

D Schanze, AB Ekici, M Gawlik… - American Journal of …, 2011 - Wiley Online Library
In the genome‐wide association study (GWAS) on schizophrenia [O'Donovan et al.(2008);
Nat Genet 40: 1053–1055] a UK‐sample of 479 cases with DSM‐IV schizophrenia was …

A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation

WTCC Consortium… - Biological …, 2014 - Elsevier
Background Genome-wide association studies (GWAS) have identified several loci
associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis …

Genomic insights into schizophrenia

MJ Owen - Royal Society Open Science, 2023 - royalsocietypublishing.org
Schizophrenia is a common, complex, heterogeneous psychiatric syndrome which can have
profound impacts on affected individuals and imposes significant burdens on society …

Schizophrenia genetics: putting all the pieces together

SL Girard, PA Dion, GA Rouleau - Current neurology and neuroscience …, 2012 - Springer
Schizophrenia is a major mental disorder characterized by a deep disruption of the thinking
process and of emotional response. For many decades, genetics studies have yielded little …

Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain

AL Richards, L Jones, V Moskvina, G Kirov… - Molecular …, 2012 - nature.com
It is widely thought that alleles that influence susceptibility to common diseases, including
schizophrenia, will frequently do so through effects on gene expression. As only a small …

Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach

DM Ruderfer, AW Charney, B Readhead… - The Lancet …, 2016 - thelancet.com
Background Therapeutic treatments for schizophrenia do not alleviate symptoms for all
patients and efficacy is limited by common, often severe, side-effects. Genetic studies of …

Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies

J Arnedo, DM Svrakic, C Del Val… - American Journal of …, 2015 - Am Psychiatric Assoc
Objective: The authors sought to demonstrate that schizophrenia is a heterogeneous group
of heritable disorders caused by different genotypic networks that cause distinct clinical …

Schizophrenia: a review of genetic studies

MT Tsuang, WS Stone, SV Faraone - Harvard Review of Psychiatry, 1999 - Taylor & Francis
Despite the complexities of schizophrenia, notable progress has been achieved in its
diagnosis and treatment over the last 25 years. In this article we review the genetic research …

Genetic assessment of additional endophenotypes from the Consortium on the Genetics of Schizophrenia Family Study

TA Greenwood, LC Lazzeroni, ME Calkins… - Schizophrenia …, 2016 - Elsevier
ABSTRACT The Consortium on the Genetics of Schizophrenia Family Study (COGS-1) has
previously reported our efforts to characterize the genetic architecture of 12 primary …