What genes are differentially expressed in individuals with schizophrenia? A systematic review
AK Merikangas, M Shelly, A Knighton, N Kotler… - Molecular …, 2022 - nature.com
Schizophrenia is a severe, complex mental disorder characterized by a combination of
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …
Evaluation of risk loci for schizophrenia derived from genome‐wide association studies in a German population
D Schanze, AB Ekici, M Gawlik… - American Journal of …, 2011 - Wiley Online Library
In the genome‐wide association study (GWAS) on schizophrenia [O'Donovan et al.(2008);
Nat Genet 40: 1053–1055] a UK‐sample of 479 cases with DSM‐IV schizophrenia was …
Nat Genet 40: 1053–1055] a UK‐sample of 479 cases with DSM‐IV schizophrenia was …
A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation
WTCC Consortium… - Biological …, 2014 - Elsevier
Background Genome-wide association studies (GWAS) have identified several loci
associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis …
associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis …
Genomic insights into schizophrenia
MJ Owen - Royal Society Open Science, 2023 - royalsocietypublishing.org
Schizophrenia is a common, complex, heterogeneous psychiatric syndrome which can have
profound impacts on affected individuals and imposes significant burdens on society …
profound impacts on affected individuals and imposes significant burdens on society …
Schizophrenia genetics: putting all the pieces together
Schizophrenia is a major mental disorder characterized by a deep disruption of the thinking
process and of emotional response. For many decades, genetics studies have yielded little …
process and of emotional response. For many decades, genetics studies have yielded little …
Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain
AL Richards, L Jones, V Moskvina, G Kirov… - Molecular …, 2012 - nature.com
It is widely thought that alleles that influence susceptibility to common diseases, including
schizophrenia, will frequently do so through effects on gene expression. As only a small …
schizophrenia, will frequently do so through effects on gene expression. As only a small …
Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach
DM Ruderfer, AW Charney, B Readhead… - The Lancet …, 2016 - thelancet.com
Background Therapeutic treatments for schizophrenia do not alleviate symptoms for all
patients and efficacy is limited by common, often severe, side-effects. Genetic studies of …
patients and efficacy is limited by common, often severe, side-effects. Genetic studies of …
Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies
Objective: The authors sought to demonstrate that schizophrenia is a heterogeneous group
of heritable disorders caused by different genotypic networks that cause distinct clinical …
of heritable disorders caused by different genotypic networks that cause distinct clinical …
Schizophrenia: a review of genetic studies
Despite the complexities of schizophrenia, notable progress has been achieved in its
diagnosis and treatment over the last 25 years. In this article we review the genetic research …
diagnosis and treatment over the last 25 years. In this article we review the genetic research …
Genetic assessment of additional endophenotypes from the Consortium on the Genetics of Schizophrenia Family Study
ABSTRACT The Consortium on the Genetics of Schizophrenia Family Study (COGS-1) has
previously reported our efforts to characterize the genetic architecture of 12 primary …
previously reported our efforts to characterize the genetic architecture of 12 primary …