A small subpopulation of cells within the bulk of tumors share features with somatic stem
cells, in that, they are capable of self-renewal, they differentiate, and are highly resistant to …

Cancer stem cells (CSCs) have been demonstrated in a variety of tumors and are thought to
act as a clonogenic core for the genesis of new tumor growth. This small subpopulation of …

Cancer is a multifactor and multistep process that is affected intrinsically by the genetic and
epigenetic makeup of tumor cells and extrinsically by the host microenvironment and …

Different mechanisms contribute to intratumor heterogeneity, including genetic mutations,
the microenvironment, and the existence of subpopulations of cancer cells with increased …

Cancer handles an estimated 7.6 million deaths worldwide per annum. A recent theory
focuses on the role Cancer Stem Cells (CSCs) in driving tumorigenesis and disease …

Stem cells are defined by their self-renewal capacity and the ability to give rise to all
differentiated progeny necessary for one specific organ. These two characteristics are also …

Cells with stem‐like properties, tumorigenic potential, and treatment‐resistant phenotypes
have been identified in many human malignancies. Based on the properties they share with …

Tumors are intricate ecosystems containing malignant components that generate adaptive
and evolutionarily driven abnormal tissues. Through self-renewal and differentiation …

Cancer stem cells (CSCs) are tumor cells that have the principal properties of self-renewal,
clonal tumor initiation capacity, and clonal long-term repopulation potential. CSCs reside in …

Recent evidence has demonstrated the existence of a small subset of the tumour mass that
is wholly responsible for the sustained growth and propagation of the tumour. This cancer …