Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels are widely expressed
in the central and peripheral nervous systems. All four isoforms (HCN1-4) are expressed in …

Hyperpolarization-activated, cyclic nucleotide-sensitive, cation non-selective (HCN)
channels are gaining attention in recent years. These ion-channels are gated by two factors …

The HCN channel family comprises of four members (HCN1-4) expressed in the heart and
nervous system. The current produced by HCN channels is known as Ih (or If or Iq). Ih has …

Background and Purpose Hyperpolarization‐activated cyclic nucleotide‐gated (HCN)
channels are encoded by four genes (HCN1–4) with distinct biophysical properties and …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels are members of the
family of the voltage gated ion channels (Sartiani et al., 2017). HCN channels are encoded …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …

Hyperpolarization-activated cation channels of the HCN gene family are crucial for the
regulation of cell excitability. Importantly, these channels play a pivotal role in the control of …

Highlights•Postsynaptic HCN channels affect neuronal intrinsic membrane properties.•
Postsynaptic HCN channels limit synaptic potential decay, summation and plasticity.•HCN …

The hyperpolarization-activated cyclic nucleotide-gated channels are cation channels that
are activated by hyperpolarizing potentials. These channels are concentrated in cortical and …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels carry a non-selective
cationic conductance, I h, which is important for modulating neuron excitability. Four genes …