Although β-cell heterogeneity was discovered more than 50 years ago, the underlying
principles have been explored only during the past decade. Islet-cell heterogeneity arises …

Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While
long known, recent technological advances and new markers have allowed the identification …

Pancreatic β-cells perform glucose-stimulated insulin secretion, a process at the center of
type 2 diabetes etiology. Efforts to understand how β-cells behave in healthy and stressful …

It is becoming increasingly apparent that not all insulin-secreting beta cells are equal. Subtle
differences exist at the transcriptomic and protein expression levels, with repercussions for …

The two main types of diabetes mellitus have distinct etiologies, yet a similar outcome: loss
of islet β-cell function that is solely responsible for the secretion of the insulin hormone to …

The overall conservation between mouse and human pancreatic development, islet
physiology and etiology of diabetes encourages the translation of novel β cell replacement …

Following differentiation during fetal development, β cells further adapt to their postnatal role
through functional maturation. While adult islets are thought to contain functionally mature β …

Pancreatic β and α cells play essential roles in maintaining glucose homeostasis. However,
the mechanisms by which these distinct cell populations are generated, expand, and mature …

Objective Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes
(T2D). However, the prevalence, plasticity and functional consequences of this cellular state …

Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …