Exposure of rats to hypoxia (7% O 2) markedly increased the level of heme oxygenase-1
(HO-1) mRNA in several tissues. Accumulation of HO-1 transcripts was also observed after …

Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that regulates the oxygen-
dependent expression of a number of genes. This transcription factor may contribute to the …

ABSTRACT A great many aspects of the anatomy and physiology of large animals are
constrained by the need to match oxygen supply to cellular metabolism and appear likely to …

Abstract Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator,
which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 …

Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor, consisting of an alpha
subunit and a beta subunit, that controls cellular responses to hypoxia. HIF α contains two …

Abstract Hypoxia-inducible factors (HIF-1 and HIF-2) are two closely related protein
complexes that activate transcription of target genes in response to hypoxia. Expression of …

Cellular response to changes in oxygen tension during normal development or pathologic
processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen-sensitive …

Heterodimeric transcription factor hypoxia inducible factor-1 (HIF-1) functions as a master
regulator of oxygen homeostasis in almost all nucleated mammalian cells. The fundamental …

Cells experiencing lowered O2 levels (hypoxia) undergo a variety of biological responses in
order to adapt to these unfavorable conditions. The master switch, orchestrating the cellular …

Overexpression of hypoxia-inducible factors (HIF), HIF-1α and HIF-2α, leads to the up-
regulation of genes involved in proliferation, angiogenesis, and glucose metabolism and is …