Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic
response in eukaryotic cells, regulating the expression of a myriad of genes involved in …

The Hypoxia Inducible Factor 1 (HIF-1) plays a major role in the cellular response to hypoxia
by regulating the expression of many genes involved in adaptive processes that allow cell …

The hypoxia-inducible transcription factors HIF-1α and HIF-2α are activated in hypoxic tumor
regions. However, their role in tumorigenesis remains controversial, as tumor growth …

The two hypoxia-inducible factors (HIF-1α and HIF-2α) are transcription factors that regulate
the response to hypoxia. Recently, the factor inhibiting HIF (FIH1) was identified as a …

Adaptive transcriptional responses to oxygen deprivation (hypoxia) are mediated by the
hypoxia-inducible factors (HIFs), heterodimeric transcription factors composed of two basic …

Hypoxia-inducible factor-1 (HIF-1) controls the expression of a number of genes such as
vascular endothelial growth factor and erythropoietin in low oxygen conditions. However, the …

Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix-PAS domain transcription factor
that is expressed in all metazoan organisms and is composed of HIF-1α and HIF-1β …

Many molecular and physiological responses to hypoxia in mammals are controlled by the
transcription factors Hypoxia-Inducible Factor-1α (HIF-1α) and HIF-2α. Their ability to …

Hypoxia inducible factor 1 (HIF-1) is a key regulator of the genes involved in the cellular
response to hypoxia. HIF consists of α and β subunits, with the α subunit being degraded …

Abstract Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding
proteins that mediate adaptive responses to reduced oxygen availability. The HIF-1β subunit …