Chronic supplementation of curcumin enhances the efficacy of antidepressants in major depressive disorder: a randomized, double-blind, placebo-controlled pilot …

JJ Yu, LB Pei, Y Zhang, ZY Wen… - Journal of clinical …, 2015 - journals.lww.com
Major depressive disorder is a devastating mental illness leading to a lifetime prevalence of
higher than 16% on individuals. The treatment delay and inevitable adverse effects are …

Curcumin as an add-on to antidepressive treatment: a randomized, double-blind, placebo-controlled, pilot clinical study

J Bergman, C Miodownik, Y Bersudsky… - Clinical …, 2013 - journals.lww.com
Objectives Depression is a widespread mental disorder in which nearly half of the affected
people have recurrent symptoms. Drug combinations may produce cumulative adverse …

Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial

J Sanmukhani, V Satodiya, J Trivedi… - Phytotherapy …, 2014 - Wiley Online Library
Curcumin, an active ingredient of Curcuma longa Linn (Zingiberaceae), has shown potential
antidepressant‐like activity in animal studies. The objectives of this trial were to compare the …

Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study

AL Lopresti, M Maes, GL Maker, SD Hood… - Journal of affective …, 2014 - Elsevier
Background Curcumin, the principal curcuminoid derived from the spice turmeric, influences
several biological mechanisms associated with major depression, namely those associated …

The role of curcumin administration in patients with major depressive disorder: mini meta‐analysis of clinical trials

D Al‐Karawi, DA Al Mamoori… - Phytotherapy Research, 2016 - Wiley Online Library
Major depression is a common, recurrent, and chronic disease that negatively affects the
quality of life and increases the risk of mortality. Several studies have demonstrated that …

Clinical use of curcumin in depression: a meta-analysis

QX Ng, SSH Koh, HW Chan, CYX Ho - Journal of the American Medical …, 2017 - Elsevier
Introduction There is growing interest in the use of curcumin, a plant polyphenol with potent
anti-inflammatory, anti-oxidant, and neuroprotective properties, as a novel antidepressant …

Curcumin in antidepressant treatments: an overview of potential mechanisms, pre‐clinical/clinical trials and ongoing challenges

Y Zhang, L Li, J Zhang - Basic & Clinical Pharmacology & …, 2020 - Wiley Online Library
Depression is one of the most common but serious psychiatric disorders affecting millions of
people globally, which has become increasingly prevalent during the past few decades. To …

A systematic review of the antidepressant effects of curcumin: Beyond monoamines theory

JN Matias, G Achete, GSS Campanari… - Australian & New …, 2021 - journals.sagepub.com
Background: Depression is a severe, chronic, and recurring mental health disorder, which
prevalence and morbimortality have increased in recent years. Several theories are …

Curcumin in depression: potential mechanisms of action and current evidence—a narrative review

T Ramaholimihaso, F Bouazzaoui… - Frontiers in psychiatry, 2020 - frontiersin.org
Major depressive disorder (MDD) is one of the most prevalent and debilitating disorders.
Current available treatments are somehow limited, so alternative therapeutic approaches …

Potentials of curcumin as an antidepressant

SK Kulkarni, A Dhir, KK Akula - The Scientific World Journal, 2009 - Wiley Online Library
Major depression, a debilitating psychiatric disorder, is predicted to be the second most
prevalent human illness by the year 2020. Various antidepressants, ranging from …