A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms [S]

S Mack, S Coassin, R Rueedi, NA Yousri… - Journal of lipid …, 2017 - ASBMB
High lipoprotein (a)[Lp (a)] concentrations are an independent risk factor for cardiovascular
outcomes. Concentrations are strongly influenced by apo (a) kringle IV repeat isoforms. We …

Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein (a) Concentration: Protective Missense Variant on Lipoprotein (a) …

MA Said, MW Yeung, YJ van de Vegte… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lipoprotein (a)(Lp [a]) is associated with coronary artery disease (CAD) but also
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …

[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels

W Lu, YC Cheng, K Chen, H Wang… - Human molecular …, 2015 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is an independent risk factor for atherosclerosis-related
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …

Genome-Wide Association Study Highlights APOH as a Novel Locus for Lipoprotein(a) Levels—Brief Report

M Hoekstra, HY Chen, J Rong, L Dufresne… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lp (a)(lipoprotein [a]) is an independent risk factor for cardiovascular diseases
and plasma levels are primarily determined by variation at the LPA locus. We performed a …

The relationship between lipoprotein (a) and risk of cardiovascular disease: a Mendelian randomization analysis

S Wang, L Zha, J Chen, D Du, D Liu, M Zhong… - European Journal of …, 2022 - Springer
Abstract Background Lipoprotein (a)[Lp (a)] is one of the residual risk factors for
cardiovascular disease (CVD) in the setting of optimal low-density lipoprotein cholesterol …

Genome-and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study

J Li, LA Lange, J Sabourin, Q Duan, W Valdar… - Journal of human …, 2015 - nature.com
Abstract Lipoprotein (a)(Lp (a)) is an independent risk factor for cardiovascular disease. Lp
(a) levels in African Americans (AAs) are much higher compared with that in European …

Lipoprotein (a): genotype–phenotype relationship and impact on atherogenic risk

B Enkhmaa, E Anuurad, W Zhang, T Tran… - … syndrome and related …, 2011 - liebertpub.com
In 2010, more than 45 years after the initial discovery of lipoprotein (a)[Lp (a)] by Kare Berg,
an European Atherosclerosis Society Consensus Panel recommended screening for …

Lipoprotein (a) an elusive cardiovascular risk factor

L Berglund, R Ramakrishnan - Arteriosclerosis, thrombosis, and …, 2004 - Am Heart Assoc
Lipoprotein (a)[Lp (a)], is present only in humans, Old World nonhuman primates, and the
European hedgehog. Lp (a) has many properties in common with low-density lipoprotein …

Association of polymorphisms of the apolipoprotein (a) gene with lipoprotein (a) levels and myocardial infarction

SR Holmer, C Hengstenberg, HG Kraft, B Mayer… - Circulation, 2003 - Am Heart Assoc
Background—Serum lipoprotein (a)[Lp (a)] concentration is largely determined by variability
at the apolipoprotein (a) gene locus. Most prominent effects relate to polymorphisms in the …