Cystic fibrosis (CF), which is caused by mutations in CFTR, affects many tissues, including
the lung. Submucosal gland serous acinar cells are primary sites of fluid secretion and …

Airway submucosal glands are important sites of cystic fibrosis transmembrane conductance
regulator (CFTR) chloride (Cl−) channel expression and fluid secretion in the airway …

Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) Cl− channel, which mediates transepithelial Cl− transport in a variety of …

Airway submucosal glands are sites of high expression of the cystic fibrosis transmembrane
conductance regulator (CFTR) Cl− channel and contribute to fluid homeostasis in the lung …

Cystic fibrosis (CF) results from mutations that disrupt CF transmembrane conductance
regulator (CFTR), an anion channel found mainly in apical membranes of epithelial cells. CF …

Cytoplasmic Ca 2+ is a master regulator of airway physiology; it controls fluid, mucus, and
antimicrobial peptide secretion, ciliary beating, and smooth muscle contraction. The focus of …

Cystic fibrosis (CF) airway disease arises from defective innate defenses, especially
defective mucus clearance of microorganisms. Airway submucosal glands secrete most …

Airway submucosal glands have been proposed as a primary site for initiating and
sustaining airway disease in cystic fibrosis (CF). However, it has been difficult to define the …

The serous acini of airway submucosal glands are important for fluid secretion in the lung.
Serous cells are also sites of expression of the cystic fibrosis transmembrane conductance …

Cystic fibrosis (CF) is caused by a nonfunctional chloride and bicarbonate ion channel (CF
transmembrane regulator [CFTR]), but the link to the phenomenon of stagnant mucus is not …