Our current understanding of cystic fibrosis (CF) has revealed that the biophysical properties
of mucus play a considerable role in the pathogenesis of the disease in view of the fact that …

Cystic fibrosis (CF) is an inherited disorder caused by mutations in the gene encoding for the
cystic fibrosis transmembrane conductance regulator (CFTR) protein, an ATP-gated chloride …

Work addressing whether cystic fibrosis transmembrane conductance regulator (CFTR)
plays a role in regulating organelle pH has remained inconclusive. We engineered a pH …

Cystic fibrosis (CF) is characterized by abnormal regulation of epithelial ion and fluid
transport due to mutations in the CF transmembrane conductance regulator (CFTR), an …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) affect the
homeostasis of chloride flux by epithelial cells. This has deleterious consequences …

Using cell culture models, we have investigated the relative importance of cystic fibrosis
transmembrane conductance regulator (CFTR) and calcium-activated chloride channels …

Cystic fibrosis (CF) is caused by defective cyclic AMP-dependent cystic fibrosis
transmembrane conductance regulator Cl-channels. Thus, CF epithelia fail to transport Cl …

The mechanisms underlying mucus-associated pathologies in cystic fibrosis (CF) remain
obscure. However, recent studies indicate that CF transmembrane conductance regulator …

Cystic fibrosis (CF) is an autosomal recessive disorder characterized by mutations in the
cystic fibrosis transmembrane conductance regulator gene, which causes multifunctional …

Pilewski, Joseph M., and Raymond A. Frizzell. Role of CFTR in Airway Disease. Physiol.
Rev. 79, Suppl.: S215–S255, 1999.—Cystic fibrosis (CF) is caused by mutations in the gene …