Our objective in this study was to determine the effect of changes in luminal and cytoplasmic
pH on cystic fibrosis transmembrane regulator (CFTR) Cl− conductance (G Cl). We …

In the cystic fibrosis (CF) patient, lung function decreases throughout life as a result of
continuous cycles of infection, particularly with Pseudomonas aeruginosa and …

Background Bacterial colonization in cystic fibrosis (CF) lungs has been directly associated
to the loss of CFTR function, and/or secondarily linked to repetitive cycles of chronic …

Defects of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein
affect the homeostasis of chloride, bicarbonate, sodium, and water in the airway surface …

We have demonstrated previously the regulation of Cl−/HCO 3− exchange activity by the
cystic fibrosis transmembrane conductance regulator (CFTR) in model systems of cells …

In cystic fibrosis (CF), a lack of functional CF transmembrane conductance regulator (CFTR)
chloride channels causes defective secretion by submucosal glands (SMGs), leading to …

The pathogenesis of mucoinfective lung disease in cystic fibrosis (CF) patients likely
involves poor mucus clearance. A recent model of mucus clearance predicts that mucus flow …

Cystic fibrosis (CF) is caused by mutated CF transmembrane conductance regulator (CFTR)
and is characterized by robust airway inflammation and accumulation of apoptotic cells …

The cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein is a cAMP-
activated anion channel that is critical for regulating fluid and ion transport across the …

Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent chloride
channel in epithelial cells; recently, we identified it in mast cells. Previous work that we …