Viral infection is a highly dynamic process, which lead to constant evolutionary changes on
both sides of the viral–host interface. The high mutation rates of viruses, coupled with short …

Host range is a viral property reflecting natural hosts that are infected either as part of a
principal transmission cycle or, less commonly, as “spillover” infections into alternative hosts …

Viruses are very diverse and they infect organisms from all domains of life and across all
ecosystems, but related viruses often infect very different types of organisms, pointing to their …

How virulence evolves after a virus jumps to a new host species is central to disease
emergence. Our current understanding of virulence evolution is based on insights drawn …

Emerging viral diseases are often the product of a host shift, where a pathogen jumps from
its original host into a novel species. Phylogenetic studies show that host shifts are a …

Highlights•The generation of host-range mutants is usually not a limiting factor in
viruses.•Antagonistic pleiotropy partially limits the evolution of generalist viruses.•Epistasis …

Despite the public health burden due to emerging viruses, little is known about the
evolutionary processes that allow viruses to jump species barriers and establish productive …

New viral diseases are emerging continuously. Viruses adapt to new environments at
astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many …

Population genetic diversity plays a prominent role in viral evolution, pathogenesis, immune
escape, and drug resistance. Different mechanisms are responsible for creating and …

The infection of cells by multiple copies of a given virus can impact viral evolution in a variety
of ways, yet some of the most basic evolutionary dynamics remain underexplored. Using …