Determining the binding mode and binding affinity constant of tyrosine kinase inhibitor PD153035 to DNA using optical tweezers

CM Cheng, YJ Lee, WT Wang, CT Hsu, JS Tsai… - Biochemical and …, 2011 - Elsevier
Accurately predicting binding affinity constant (KA) is highly required to determine the
binding energetics of the driving forces in drug–DNA interactions. Recently, PD153035 …

Carboplatin interaction with calf-thymus DNA: A FTIR spectroscopic approach

DK Jangir, G Tyagi, R Mehrotra, S Kundu - Journal of Molecular Structure, 2010 - Elsevier
Carboplatin is a chemotherapeutic drug, used for the treatment of different types of cancers,
particularly solid tumors. Carboplatin, like other platinum containing drugs, exerts its …

Probing the interaction of an antiviral drug 8-Methoxy-3-nitro-2-(4-methoxyphenyl)-2H-chromene (MNC) with DNA by experimental and computational approach

DK Sahoo, NP Mishra - Journal of Molecular Structure, 2024 - Elsevier
Deoxyribonucleic acid (DNA) is a major target in research pertaining to antiviral and
anticancer therapies since it is the principal genetic material that controls vital biological …

Molecular modeling, simulation and principal component analysis of binding of resveratrol and its analogues with DNA

MS Nair, A Shukla - Journal of Biomolecular Structure and …, 2020 - Taylor & Francis
Abstract Structure-based drug designing has become a significant subject of research, and
several clinically promising DNA binding compounds were evolved using this technique …

Fluorescence and circular dichroism studies on binding and conformational aspects of an anti-leukemic drug with DNA

AH Hegde, J Seetharamappa - Molecular biology reports, 2014 - Springer
In the present study, we have explored the mode of binding of an anti-leukemic drug,
imatinib (IMT) mesylate with DNA and resulting conformational changes in DNA double …

Determination of the DNA binding properties of a novel PARP inhibitor MK-4827 with calf-thymus DNA by molecular simulations and detailed spectroscopic …

H Yang, Q Zeng, Z He, D Wu, H Li - New Journal of Chemistry, 2019 - pubs.rsc.org
The binding interaction of niraparib (MK-4827), a poly (ADP-ribose) polymerase inhibitor,
with calf thymus deoxyribonucleic acid (ctDNA) has been explored by various theoretical …

Interaction of diplacone and eriodictyol with DNA by multi-spectroscopic and molecular modelling methods

H Liu, H Wang, S Wu, X Jia, W Tang - Journal of Molecular Structure, 2022 - Elsevier
Diplacone was a C-geranylated flavanone derivative with great antioxidation and anti-
inflammatory activity. Its structure could be identified as eriodictyol with a C 10 side chain …

In vitro DNA binding studies of lenalidomide using spectroscopic in combination with molecular docking techniques

L Xu, YX Hu, YC Li, L Zhang, HX Ai, YF Liu… - Journal of Molecular …, 2018 - Elsevier
In the present work, the binding interaction between lenalidomide (LEN) and calf thymus
DNA (ct-DNA) was systematically studied by using fluorescence, ultraviolet–visible (UV–vis) …

Comparative study of two cephalosporin antibiotics binding to calf thymus DNA by multispectroscopy, electrochemistry, and molecular docking

SC Huang, LY Cheng, J Yang, YJ Hu - Luminescence, 2020 - Wiley Online Library
The over‐use of antibiotics has caused a number of problems such as contamination of
antibiotic residues and virus resistance, and therefore has attracted global attention. In this …

Spectroscopic and molecular docking studies on the interaction of antiviral drug nevirapine with calf thymus DNA

NH Moghadam, S Salehzadeh… - … Nucleotides and Nucleic …, 2017 - Taylor & Francis
The interaction of calf thymus DNA with nevirapine at physiological pH was studied by using
absorption, circular dichroism, viscosity, differential pulse voltammetry, fluorescence …