[HTML][HTML] Upregulating Nrf2-dependent antioxidant defenses in Pacific oysters Crassostrea gigas: Investigating the Nrf2/Keap1 pathway in bivalves

NM Danielli, R Trevisan, DF Mello, K Fischer… - … and Physiology Part C …, 2017 - Elsevier
Abstract Analysis of the Pacific oyster Crassostrea gigas annotated genome revealed genes
with conserved sequences belonging to typical cap 'n'collar Nrf2 domain, a major player in …

Contrasting effects of a classic Nrf2 activator, tert-butylhydroquinone, on the glutathione-related antioxidant defenses in Pacific oysters, Crassostrea gigas

NM Danielli, R Trevisan, DF Mello, K Fischer… - Marine environmental …, 2017 - Elsevier
Nrf2 is a well-known transcription factor controlling a number of antioxidant defense-related
genes, which is understudied in bivalves. In this study, oysters Crassostrea gigas were …

The Nrf2 molecule trigger antioxidant defense against acute benzo (a) pyrene exposure in the thick shell mussel Mytilus coruscus

P Qi, Z Tang - Aquatic Toxicology, 2020 - Elsevier
The NF-E2-related factor 2 (Nrf2), an ubiquitous, evolutionarily conserved transcription
factor, acts as a major sensor of oxidative stress in cells. In the present study, a Nrf2 …

The role of Nrf2-Keap1 signaling pathway in the antioxidant defense response induced by PAHs in the calm Ruditapes philippinarum

H Wang, L Pan, L Si, J Miao - Fish & shellfish immunology, 2018 - Elsevier
The NF-E2-related factor 2 (Nrf2) is a master regulator of cellular responses against
environmental stresses. In this study we cloned the full-length cDNAs of the RpNrf2 …

Unraveling the protective role of Nrf2 in molluscs: Insights into mitochondrial and apoptosis pathways in the defense against Bap-induced oxidative stress

L Qiu, X Chen, B Guo, Z Liao, I Buttino, X Yan, P Qi - Aquatic Toxicology, 2023 - Elsevier
Benzopyrene (Bap) is a major constituent of petroleum pollutants commonly found in aquatic
environments, and its mutagenic and carcinogenic properties have adverse effects on …

The molecular mechanism of Nrf2-Keap1 signaling pathway in the antioxidant defense response induced by BaP in the scallop Chlamys farreri

H Wang, L Pan, R Xu, L Si, X Zhang - Fish & Shellfish Immunology, 2019 - Elsevier
In this study, we cloned the full-length cDNA of the Kelch-like ECH-associated protein 1
(Keap1) from the scallops Chlamys farreri (C. farreri). Sequences alignment and …

Effects of Nrf2-Keap1 signaling pathway on antioxidant defense system and oxidative damage in the clams Ruditapes philippinarum exposure to PAHs

H Wang, L Pan, L Si, R Ji, Y Cao - Environmental Science and Pollution …, 2021 - Springer
Abstract NF-E2-related factor 2 (Nrf2) is a master regulator of antioxidant defense system
which can maintain the oxidation balance in the cell. In our previous study, we first cloned …

ChIP-seq identifies McSLC35E2 as a novel target gene of McNrf2 in Mytilus coruscus, highlighting its role in the regulation of oxidative stress response in marine …

L Qiu, X Chen, L Zhu, R Yao, P Qi - Frontiers in Physiology, 2023 - frontiersin.org
NF-E2-related factor 2 (Nrf2) plays a crucial role in the oxidative regulatory process, which
could trigger hundreds of antioxidant elements to confront xenobiotics. In the previous study …

Identification of the Nrf2–Keap1 pathway in the European eel Anguilla anguilla: role for a transcriptional regulation of antioxidant genes in aquatic organisms

ME Giuliani, F Regoli - Aquatic Toxicology, 2014 - Elsevier
Antioxidant defences play a central role in cell protection against a wide variety of
environmental stressors, their variations being thus frequently studied to reveal oxidative …

The role of Nrf2 signaling pathway in the mud crab (Scylla paramamosain) in response to Vibrio parahaemolyticus infection

CH Cheng, HL Ma, GX Liu, SG Fan, YQ Deng… - Fish & Shellfish …, 2023 - Elsevier
The transcription factor Nrf2 plays vital roles in detoxification and antioxidant enzymes
against oxidative stress. However, the function of Nrf2 in crustaceans is not well studied. In …