CD18 integrin and CD54-dependent neutrophil adhesion to cytokine-stimulated human hepatocytes

AR Nagendra, JK Mickelson… - American Journal of …, 1997 - journals.physiology.org
We investigated the hypothesis that CD54 (intercellular adhesion molecule-1) expressed on
hepatocytes will support beta2-integrin (CD18)-dependent adhesion of neutrophils. An in …

[PDF][PDF] Functional inactivation of neutrophils with a Mac‐1 (CD11b/CD18) monoclonal antibody protects against ischemia‐reperfusion injury in rat liver

H Jaeschke, A Farhood, AP Bautista, Z Spolarics… - …, 1993 - Wiley Online Library
The role of neutrophil CD11b/CD18 (Mac‐1) adhesion proteins in the pathogenesis of
hepatic reperfusion injury was investigated in an experimental model. Male Fischer rats …

Neutrophils contribute to hepatic ischemia-reperfusion injury by a CD18-independent mechanism

LA Langdale, LC Flaherty, HD Liggitt… - Journal of leukocyte …, 1993 - academic.oup.com
Hepatic ischemia-reperfusion injury is reported to be modulated by neutrophils (PMNs). The
adhesion and emigration of PMNs that precede tissue inflammation and necrosis in other …

The role of CD14 in neutrophil recruitment within the liver microcirculation during endotoxemia

EF McAvoy, B McDonald, SA Parsons… - The Journal of …, 2011 - journals.aai.org
During Gram-negative sepsis and endotoxemia, CD14 is essential for the recognition of LPS
by the TLR4 complex and subsequent generation of systemic inflammation. However, CD14 …

[PDF][PDF] Inflammatory cytokines up‐regulate intercellular adhesion molecule‐1 expression on primary cultured mouse hepatocytes and T‐lymphocyte adhesion

M Morita, Y Watanabe, T Akaike - Hepatology, 1994 - Wiley Online Library
We investigated the effect of inflammatory cytokines on the intercellular adhesion molecule‐
1 expression on primary cultured murine hepatocytes. Tumor necrosis factor‐α, interferon‐γ …

Intercellular adhesion molecule-1 and CD18 are involved in neutrophil adhesion and its cytotoxicity to cultured sinusoidal endothelial cells in rats

S Sakamoto, T Okanoue, Y Itoh, K Sakamoto… - Hepatology, 1997 - journals.lww.com
The expression of several adhesion molecules is increased on the hepatic sinusoidal
endothelial cells (SECs) in various liver diseases. The objective of this study is to assess the …

Complement and tumor necrosis factor-α contribute to Mac-1 (CD11b/CD18) up-regulation and systemic neutrophil activation during endotoxemia in vivo

R Witthaut, A Farhood, CW Smith… - Journal of Leucocyte …, 1994 - academic.oup.com
The increased expression of Mac-1 (CD11b/CD18) adhesion glycoproteins on neutrophils
was studied using flow cytometry in male Fischer 344 rats treated with 5 mg/kg Salmonella …

Mac-1 (CD11b/CD18) and intercellular adhesion molecule-1 in ischemia-reperfusion injury of rat liver

A Kobayashi, H Imamura, M Isobe… - American Journal …, 2001 - journals.physiology.org
The chronological expression (over 24 h) of two adhesion molecules [intercellular adhesion
molecule-1 (ICAM-1) and CD11b/CD18 (Mac-1)] and the extent of liver damage, including …

[PDF][PDF] Hepatocellular expression of lymphocyte function—associated antigen 3 in chronic hepatitis

F Autschbach, SC Meuer, U Moebius, M Manns… - …, 1991 - Wiley Online Library
T lymphocyte—mediated cytolytic immune reactions are considered a major cause of
hepatocyte injury in chronic viral and autoimmune hepatitis. To further investigate local …

Sequestration of neutrophils in the hepatic vasculature during endotoxemia is independent of β2 integrins and intercellular adhesion molecule-1

H Jaeschke, A Farhood, MA Fisher, CW Smith - Shock, 1996 - journals.lww.com
Antibodies against cellular adhesion molecules protect against neutrophil-induced hepatic
injury during ischemia-reperfusion and endotoxemia. To test if p2 integrins on neutrophils …