The vicious cycle of myostatin signaling in sarcopenic obesity: myostatin role in skeletal muscle growth, insulin signaling and implications for clinical trials
LA Consitt, BC Clark - The Journal of frailty & aging, 2018 - Springer
The age-related loss of skeletal muscle (sarcopenia) is a major health concern as it is
associated with physical disability, metabolic impairments, and increased mortality. The …
associated with physical disability, metabolic impairments, and increased mortality. The …
Myostatin and sarcopenia: opportunities and challenges-a mini-review
TA White, NK LeBrasseur - Gerontology, 2014 - karger.com
The progressive loss of skeletal muscle mass, strength and/or function with advancing age,
termed sarcopenia, poses a major threat to independence and quality of life. Therefore …
termed sarcopenia, poses a major threat to independence and quality of life. Therefore …
Modifying muscle mass–the endocrine perspective
AM Solomon, PMG Bouloux - Journal of Endocrinology, 2006 - joe.bioscientifica.com
This review describes the major hormonal factors that determine the balance between
human skeletal muscle anabolism and catabolism in health and disease, with specific …
human skeletal muscle anabolism and catabolism in health and disease, with specific …
Myostatin: more than just a regulator of muscle mass
The presence of sufficient skeletal muscle mass is of paramount importance for body
function and the myostatin cascade is known to inhibit muscle growth in mammals. In …
function and the myostatin cascade is known to inhibit muscle growth in mammals. In …
Challenges and future prospects of targeting myostatin/activin a signaling to treat diseases of muscle loss and metabolic dysfunction
SJ Lee, S Bhasin, L Klickstein… - The Journals of …, 2023 - academic.oup.com
Over the past 25 years, considerable progress has been made in terms of elucidating the
regulatory and signaling mechanisms underlying the control of skeletal muscle mass by …
regulatory and signaling mechanisms underlying the control of skeletal muscle mass by …
The role of myostatin in muscle wasting: an overview
Y Elkina, S von Haehling, SD Anker… - Journal of cachexia …, 2011 - Springer
Myostatin is an extracellular cytokine mostly expressed in skeletal muscles and known to
play a crucial role in the negative regulation of muscle mass. Upon the binding to activin …
play a crucial role in the negative regulation of muscle mass. Upon the binding to activin …
Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice
JPG Camporez, MC Petersen… - Proceedings of the …, 2016 - National Acad Sciences
Sarcopenia, or skeletal muscle atrophy, is a debilitating comorbidity of many physiological
and pathophysiological processes, including normal aging. There are no approved …
and pathophysiological processes, including normal aging. There are no approved …
Skeletal muscle myostatin gene expression and sarcopenia in overweight and obese middle‐aged and older adults
AS Ryan, G Li - JCSM clinical reports, 2021 - Wiley Online Library
Background Myostatin (MSTN) is a key negative regulator of muscle mass in humans and
animals, having direct and indirect influences on molecular regulators of atrophy and …
animals, having direct and indirect influences on molecular regulators of atrophy and …
The central role of myostatin in skeletal muscle and whole body homeostasis
Myostatin is a powerful negative regulator of skeletal muscle mass in mammalian species. It
plays a key role in skeletal muscle homeostasis and has now been well described since its …
plays a key role in skeletal muscle homeostasis and has now been well described since its …
Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity
T Guo, W Jou, T Chanturiya, J Portas, O Gavrilova… - PloS one, 2009 - journals.plos.org
Myostatin (Mstn) is a secreted growth factor expressed in skeletal muscle and adipose tissue
that negatively regulates skeletal muscle mass. Mstn−/− mice have a dramatic increase in …
that negatively regulates skeletal muscle mass. Mstn−/− mice have a dramatic increase in …