The age-related loss of skeletal muscle (sarcopenia) is a major health concern as it is
associated with physical disability, metabolic impairments, and increased mortality. The …

The progressive loss of skeletal muscle mass, strength and/or function with advancing age,
termed sarcopenia, poses a major threat to independence and quality of life. Therefore …

This review describes the major hormonal factors that determine the balance between
human skeletal muscle anabolism and catabolism in health and disease, with specific …

The presence of sufficient skeletal muscle mass is of paramount importance for body
function and the myostatin cascade is known to inhibit muscle growth in mammals. In …

Over the past 25 years, considerable progress has been made in terms of elucidating the
regulatory and signaling mechanisms underlying the control of skeletal muscle mass by …

Myostatin is an extracellular cytokine mostly expressed in skeletal muscles and known to
play a crucial role in the negative regulation of muscle mass. Upon the binding to activin …

Sarcopenia, or skeletal muscle atrophy, is a debilitating comorbidity of many physiological
and pathophysiological processes, including normal aging. There are no approved …

Background Myostatin (MSTN) is a key negative regulator of muscle mass in humans and
animals, having direct and indirect influences on molecular regulators of atrophy and …

Myostatin is a powerful negative regulator of skeletal muscle mass in mammalian species. It
plays a key role in skeletal muscle homeostasis and has now been well described since its …

Myostatin (Mstn) is a secreted growth factor expressed in skeletal muscle and adipose tissue
that negatively regulates skeletal muscle mass. Mstn−/− mice have a dramatic increase in …