Numerous important observations concerning the pathogenesis of infective endocarditis
have been made over the past 18 years. Many of these observations have been obtained …

It WAS about 100 yr ago that bacteria were identified as the cause of infective endocarditis.
Subsequently, there was a long period of clinical observation, during which time the natural …

The results of studies performed with animal models of experimental infective endocarditis
have provided valuable information about the pathophysiology, natural history, and …

BACKGROUND It is well recognized (3, 8, 50) that normal vascular endothelium is refractory
to the development of infection and that preexisting endocardial lesions are required for the …

It seems appropriate in a symposium dedicated to the examination of septicemia, that one of
the topics for discussion should be the examination of the factors which allow circulating …

Three aspects of our current understanding of the pathogenesis of infective endocarditis are
reviewed: the size of the infected vegetation, host defence mechanisms and conditions …

Intravascular or cardiac endothelial lesions may become colonized during bacteraemic
episodes and lead to the development of bacterial endocarditis (BE). It has therefore long …

T he panelists who covered the area of infective endo-carditis are among those investigators
who, in the recent past, have contributed the most to our understanding of the pathogenesis …

Publisher Summary This chapter describes a rabbit model of bacterial endocarditis, in which
the white New Zealand female rabbits weighing 2–2.5 kg are the most commonly used. The …

Some details of 544 episodes of infective endocarditis occurring in 541 patients during 1981
and 1982 are reported. The mean age of patients was 51.6 years and there was a greater …