Depression and Alzheimer's disease: neurobiological links and common pharmacological targets
Depression is one of the most prevalent and life-threatening forms of mental illnesses,
whereas Alzheimer's disease is a neurodegenerative disorder that affects more than 37 …
whereas Alzheimer's disease is a neurodegenerative disorder that affects more than 37 …
Understanding neuropsychiatric symptoms in Alzheimer's disease: challenges and advances in diagnosis and treatment
Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) affect up to 97% of AD
patients, with an estimated 80% of current AD patients experiencing these symptoms …
patients, with an estimated 80% of current AD patients experiencing these symptoms …
Antipsychotics for the treatment of behavioral and psychological symptoms of dementia (BPSD)
R Liperoti, C Pedone… - Current …, 2008 - ingentaconnect.com
Behavioral and psychological symptoms of dementia (BPSD), ie verbal and physical
aggression, agitation, psychotic symptoms (hallucinations and delusions), sleep …
aggression, agitation, psychotic symptoms (hallucinations and delusions), sleep …
Grouping of behavioural and psychological symptoms of dementia
RM Van Der Linde, T Dening… - … journal of geriatric …, 2014 - Wiley Online Library
Objective A wide range of behavioural and psychological symptoms (BPSD) are common in
dementia, and it has been suggested that groups of correlated symptoms should be studied …
dementia, and it has been suggested that groups of correlated symptoms should be studied …
Neuropathology of depression in Alzheimer's disease: current knowledge and the potential for new treatments
AA Khundakar, AJ Thomas - Journal of Alzheimer's Disease, 2015 - content.iospress.com
Depression is among the most common behavioral and psychological symptoms of
dementia, and leads to more rapid decline and higher mortality. Treatment for depression in …
dementia, and leads to more rapid decline and higher mortality. Treatment for depression in …
Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease
MKP Lai, SWY Tsang, PT Francis, MM Esiri, J Keene… - Brain research, 2003 - Elsevier
Previous studies have implicated brain serotonin 5-HT1A receptors in several CNS
functions, including cognition, mood and emotional states. In Alzheimer disease (AD) …
functions, including cognition, mood and emotional states. In Alzheimer disease (AD) …
Behavioral correlates of cerebrospinal fluid amino acid and biogenic amine neurotransmitter alterations in dementia
Y Vermeiren, N Le Bastard, A Van Hemelrijck… - Alzheimer's & …, 2013 - Elsevier
Background Behavioral and psychological signs and symptoms of dementia (BPSD) are a
heterogeneous group of behavioral and psychiatric disturbances occurring in dementia …
heterogeneous group of behavioral and psychiatric disturbances occurring in dementia …
The serotonin transporter in Alzheimer's and Parkinson's disease
R Mössner, A Schmitt, Y Syagailo, M Gerlach… - Advances in Research …, 2000 - Springer
The etiology of late-onset Alzheimer's disease (AD) and idiopathic Parkinson's disease (PD)
is not known. In both disorders there is an extensive degeneration of serotonergic neurons …
is not known. In both disorders there is an extensive degeneration of serotonergic neurons …
Depression in neurodegenerative diseases: Common mechanisms and current treatment options
CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …
cause of disability worldwide. This neurological condition is commonly associated with …
The roles of serotonin in neuropsychiatric disorders
The serotonergic system extends throughout the central nervous system (CNS) and the
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …