Cholinergic–serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease

M Garcia-Alloza, FJ Gil-Bea, M Diez-Ariza… - Neuropsychologia, 2005 - Elsevier
Neuropsychiatric symptoms seen in Alzheimer's disease (AD) are not simply a consequence
of neurodegeneration, but probably result from differential neurotransmitter alterations …

Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients

DE Lorke, G Lu, E Cho, DT Yew - BMC neuroscience, 2006 - Springer
Background It has been hypothesized that alterations of the serotonergic system contribute
to neuropsychiatric symptoms in Alzheimer disease (AD). Cellular expressions of the two …

Role of serotonin in Alzheimer's disease: a new therapeutic target?

WJ Geldenhuys, CJ Van der Schyf - CNS drugs, 2011 - Springer
Mounting evidence accumulated over the past few years indicates that the neurotransmitter
serotonin plays a significant role in cognition. As a drug target, serotonin receptors have …

Impact of behavioral subsyndromes on cognitive decline in Alzheimer's disease: data from the ICTUS study

M Canevelli, N Adali, C Cantet, S Andrieu, G Bruno… - Journal of …, 2013 - Springer
Behavioral and psychological symptoms of dementia (BPSD) represent common
manifestations among patients affected by Alzheimer's disease (AD). Some reports have …

Behavioral and psychological symptoms of dementia (BPSD): a current focus for clinicians, researchers, caregivers, and governmental agencies

SI Finkel - Contemporary neuropsychiatry, 2001 - Springer
The behavioral and psychological symptoms of dementia (BPSD) are an area of clinical and
research attention that has grown significantly during the past decade. It is now recognized …

The VTA dopaminergic system as diagnostic and therapeutical target for Alzheimer's disease

P Krashia, E Spoleti, M D'Amelio - Frontiers in Psychiatry, 2022 - frontiersin.org
Neuropsychiatric symptoms (NPS) occur in nearly all patients with Alzheimer's Disease
(AD). Most frequently they appear since the mild cognitive impairment (MCI) stage preceding …

What is the association between depression and Alzheimer's disease?

N Tsuno, A Homma - Expert review of neurotherapeutics, 2009 - Taylor & Francis
Depression and dementia, in particular Alzheimer's disease (AD), are critically important
issues in the mental health of old age. Both conditions apparently reduce quality of life and …

5-HT systems: emergent targets for memory formation and memory alterations

A Meneses - Reviews in the Neurosciences, 2013 - degruyter.com
Drugs acting through 5-hydroxytryptamine (serotonin or 5-HT) systems modulate memory
and its alterations, although the mechanisms involved are poorly understood. 5-HT drugs …

Depression in major neurodegenerative diseases and strokes: a critical review of similarities and differences among neurological disorders

J Pagonabarraga, C Álamo, M Castellanos, S Díaz… - Brain Sciences, 2023 - mdpi.com
Depression and anxiety are highly prevalent in most neurological disorders and can have a
major impact on the patient's disability and quality of life. However, mostly due to the …

Serotonin, β‐amyloid, and cognition in Parkinson disease

V Kotagal, C Spino, NI Bohnen, R Koeppe… - Annals of …, 2018 - Wiley Online Library
Objective Serotoninergic neurotransmission may modulate β‐amyloid peptide (Aβ)
metabolism through upregulation of α‐secretase. Early Parkinson disease (PD) shows …