Cholinergic–serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease
M Garcia-Alloza, FJ Gil-Bea, M Diez-Ariza… - Neuropsychologia, 2005 - Elsevier
Neuropsychiatric symptoms seen in Alzheimer's disease (AD) are not simply a consequence
of neurodegeneration, but probably result from differential neurotransmitter alterations …
of neurodegeneration, but probably result from differential neurotransmitter alterations …
Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients
Background It has been hypothesized that alterations of the serotonergic system contribute
to neuropsychiatric symptoms in Alzheimer disease (AD). Cellular expressions of the two …
to neuropsychiatric symptoms in Alzheimer disease (AD). Cellular expressions of the two …
Role of serotonin in Alzheimer's disease: a new therapeutic target?
WJ Geldenhuys, CJ Van der Schyf - CNS drugs, 2011 - Springer
Mounting evidence accumulated over the past few years indicates that the neurotransmitter
serotonin plays a significant role in cognition. As a drug target, serotonin receptors have …
serotonin plays a significant role in cognition. As a drug target, serotonin receptors have …
Impact of behavioral subsyndromes on cognitive decline in Alzheimer's disease: data from the ICTUS study
Behavioral and psychological symptoms of dementia (BPSD) represent common
manifestations among patients affected by Alzheimer's disease (AD). Some reports have …
manifestations among patients affected by Alzheimer's disease (AD). Some reports have …
Behavioral and psychological symptoms of dementia (BPSD): a current focus for clinicians, researchers, caregivers, and governmental agencies
SI Finkel - Contemporary neuropsychiatry, 2001 - Springer
The behavioral and psychological symptoms of dementia (BPSD) are an area of clinical and
research attention that has grown significantly during the past decade. It is now recognized …
research attention that has grown significantly during the past decade. It is now recognized …
The VTA dopaminergic system as diagnostic and therapeutical target for Alzheimer's disease
P Krashia, E Spoleti, M D'Amelio - Frontiers in Psychiatry, 2022 - frontiersin.org
Neuropsychiatric symptoms (NPS) occur in nearly all patients with Alzheimer's Disease
(AD). Most frequently they appear since the mild cognitive impairment (MCI) stage preceding …
(AD). Most frequently they appear since the mild cognitive impairment (MCI) stage preceding …
What is the association between depression and Alzheimer's disease?
N Tsuno, A Homma - Expert review of neurotherapeutics, 2009 - Taylor & Francis
Depression and dementia, in particular Alzheimer's disease (AD), are critically important
issues in the mental health of old age. Both conditions apparently reduce quality of life and …
issues in the mental health of old age. Both conditions apparently reduce quality of life and …
5-HT systems: emergent targets for memory formation and memory alterations
A Meneses - Reviews in the Neurosciences, 2013 - degruyter.com
Drugs acting through 5-hydroxytryptamine (serotonin or 5-HT) systems modulate memory
and its alterations, although the mechanisms involved are poorly understood. 5-HT drugs …
and its alterations, although the mechanisms involved are poorly understood. 5-HT drugs …
Depression in major neurodegenerative diseases and strokes: a critical review of similarities and differences among neurological disorders
J Pagonabarraga, C Álamo, M Castellanos, S Díaz… - Brain Sciences, 2023 - mdpi.com
Depression and anxiety are highly prevalent in most neurological disorders and can have a
major impact on the patient's disability and quality of life. However, mostly due to the …
major impact on the patient's disability and quality of life. However, mostly due to the …
Serotonin, β‐amyloid, and cognition in Parkinson disease
Objective Serotoninergic neurotransmission may modulate β‐amyloid peptide (Aβ)
metabolism through upregulation of α‐secretase. Early Parkinson disease (PD) shows …
metabolism through upregulation of α‐secretase. Early Parkinson disease (PD) shows …