Malignant gliomas are devastating tumours that frequently kill patients within 1 year of
diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to …

Local invasion of the brain by neoplastic glial cells is a major obstacle to effective treatment
of intrinsic brain tumors. Invasion is directly related to histologic malignancy, but occurs to …

High-grade gliomas are especially difficult tumors to treat due to their invasive behavior. This
has led to extensive research focusing on arresting glioma cell migration. Cell migration …

The invasive capacity of GBM is one of the key tumoral features associated with treatment
resistance, recurrence, and poor overall survival. The molecular machinery underlying GBM …

Treatment of adult brain tumors, in particular glioblastoma, remains a significant clinical
challenge, despite modest advances in surgical technique, radiation, and …

Object. Migration and invasion are important prerequisites for the infiltrative and destructive
growth patterns of malignant gliomas. Infiltrative growth prevents complete tumor resection …

Although astrocytic brain tumors do not metastasize systemically, during tumorigenesis
glioma cells adopt an invasive phenotype that is poorly targeted by conventional therapies; …

In contrast to almost all other brain tumors, diffuse gliomas infiltrate extensively in the
neuropil. This growth pattern is a major factor in therapeutic failure. Diffuse infiltrative glioma …

Purpose The purpose of the current review is to highlight, on one hand, the fact that the
migratory pattern of glioma cells is the major obstacle to combat them with chemotherapy …

Despite advances in surgical and medical therapy, glioblastoma consistently remains a fatal
disease. Over the last 20 years, no significant increase in survival has been achieved for …