Divergent neuroimmune signatures in the cerebrospinal fluid predict differential gender-specific survival among patients with HIV-associated cryptococcal meningitis

S Okurut, DR Boulware, E Okafor, J Rhein… - Frontiers in …, 2023 - frontiersin.org
Introduction Survival among people with HIV-associated cryptococcal meningitis (CM)
remains low, particularly among women, despite the currently optimal use of antifungal …

Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis

JN Jarvis, G Meintjes, T Bicanic, V Buffa… - PLoS …, 2015 - journals.plos.org
Understanding the host immune response during cryptococcal meningitis (CM) is of critical
importance for the development of immunomodulatory therapies. We profiled the …

Cerebrospinal fluid cytokine and chemokine patterns correlate with prognosis of HIV-uninfected cryptococcal meningitis: A prospective observational study

YK Jiang, RY Wang, LH Zhou, JH Cheng… - Frontiers in …, 2022 - frontiersin.org
The cerebrospinal fluid (CSF) immune responses in HIV-uninfected cryptococcal meningitis
(CM) have not been well studied. In this study, we aimed to explore the phenotype of CSF …

Increased cryptococcal meningitis mortality among HIV negative, non-transplant patients: a single US center cohort study

G Motoa, A Pate, D Chastain, S Mann… - Therapeutic …, 2020 - journals.sagepub.com
Cryptococcal meningitis (CM) is an opportunistic fungal infection associated with human
immunodeficiency virus (HIV) and other forms of immunosuppression. We lack a clear …

The CSF Immune Response in HIV-1–Associated Cryptococcal Meningitis: Macrophage Activation, Correlates of Disease Severity, and Effect of Antiretroviral Therapy

JE Scriven, LM Graham, C Schutz… - JAIDS Journal of …, 2017 - journals.lww.com
Background: Immune modulation may improve outcome in HIV-associated cryptococcal
meningitis. Animal studies suggest alternatively activated macrophages are detrimental but …

Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis

W Sabiiti, E Robertson, MA Beale… - The Journal of …, 2014 - Am Soc Clin Investig
Background. Cryptococcal meningitis (CM) is a leading cause of HIV-associated mortality
globally. High fungal burden in cerebrospinal fluid (CSF) at diagnosis and poor fungal …

HIV-associated cryptococcal meningitis occurring at relatively higher CD4 counts

L Tugume, J Rhein, KH Hullsiek… - The Journal of …, 2019 - academic.oup.com
Background Cryptococcal meningitis can occur in persons with less-apparent
immunosuppression. We evaluated clinical characteristics and outcomes of persons with …

A preliminary study on the characteristics of Th1/Th2 immune response in cerebrospinal fluid of AIDS patients with cryptococcal meningitis

A Li, W Zhu, J Yin, X Huang, L Sun, W Hua… - BMC Infectious …, 2021 - Springer
Abstract Background Cryptococcal Meningitis (CM) is a common opportunistic infection in
the late stage of acquired immunodeficiency syndrome (AIDS). Despite the wide use of …

Determinants of mortality in a combined cohort of 501 patients with HIV-associated Cryptococcal meningitis: implications for improving outcomes

JN Jarvis, T Bicanic, A Loyse… - Clinical infectious …, 2014 - academic.oup.com
Background. Cryptococcal meningitis (CM) is a leading cause of death in individuals
infected with human immunodeficiency virus (HIV). Identifying factors associated with …

Incidence, clinical presentation, and outcome of HIV-1-associated cryptococcal meningitis during the highly active antiretroviral therapy era: a nationwide cohort study

M Touma, LD Rasmussen, R Martin-Iguacel… - Clinical …, 2017 - Taylor & Francis
Background Human immunodeficiency virus (HIV) infection with advanced
immunosuppression predisposes to cryptococcal meningitis (CM). We describe the …