Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening

Y Tabara, H Osawa, R Kawamoto, H Onuma… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE—The present study was conducted to confirm possible associations between
candidate genes from genome-wide association studies and type 2 diabetes in Japanese …

Genome-wide scan for type 2 diabetes loci in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25

MCY Ng, WY So, NJ Cox, VKL Lam, CS Cockram… - Diabetes, 2004 - Am Diabetes Assoc
We conducted an autosomal genome scan to map loci for type 2 diabetes in a Hong Kong
Chinese population. We studied 64 families, segregating type 2 diabetes, of which 57 had at …

Genomics of type 2 diabetes mellitus: implications for the clinician

ES Stolerman, JC Florez - Nature Reviews Endocrinology, 2009 - nature.com
Our understanding of the genetics of type 2 diabetes mellitus (T2DM) has changed, in part
owing to implementation of genome-wide association studies as a method for unraveling the …

Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families

P Concannon, HA Erlich, C Julier, G Morahan… - Diabetes, 2005 - Am Diabetes Assoc
Type 1 diabetes is a common, multifactorial disease with strong familial clustering (genetic
risk ratio [λS]∼ 15). Approximately 40% of the familial aggregation of type 1 diabetes can be …

Analysis of candidate genes for susceptibility to type I diabetes: a case-control and family-association study of genes on chromosome 2q31–35

D Owerbach, FJ Naya, MJ Tsai, SV Allander… - Diabetes, 1997 - Am Diabetes Assoc
Recent genome searches suggest a putative linkage of many loci to susceptibility to type I
diabetes. The chromosome 2q31–35 region is reported to be linked to susceptibility to type I …

Genetics of type 2 diabetes: pathophysiologic and clinical relevance

C Herder, M Roden - European journal of clinical investigation, 2011 - Wiley Online Library
Eur J Clin Invest 2011; 41 (6): 679–692 Abstract Background Recent genome‐wide
association studies enlarged our knowledge about the genetic background of type 2 …

Genetic linkage and association studies of Type I diabetes: challenges and rewards

LL Field - Diabetologia, 2002 - Springer
Family and twin studies have shown clearly that Type I (insulin-dependent) diabetes mellitus
has a genetic basis. However, only within the past decade has it been possible to …

Genome-wide association study identifies three novel loci for type 2 diabetes

K Hara, H Fujita, TA Johnson… - Human molecular …, 2014 - academic.oup.com
Although over 60 loci for type 2 diabetes (T2D) have been identified, there still remains a
large genetic component to be clarified. To explore unidentified loci for T2D, we performed a …

Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q

F Takeuchi, Y Ochiai, M Serizawa, K Yanai… - Journal of human …, 2008 - nature.com
To systematically evaluate genetic susceptibility to type 2 diabetes (T2D) in “candidate”
regions on chromosomes 1q, 3q and 12q, we examined disease association by using a total …

The genetics of type 2 diabetes: a realistic appraisal in 2008

JC Florez - The Journal of Clinical Endocrinology & Metabolism, 2008 - academic.oup.com
Context: Over the last few months, genome-wide association studies have contributed
significantly to our understanding of the genetic architecture of type 2 diabetes. If and how …