Background: The metabolic syndrome is associated with sarcopenia. Decreased serum
levels of Vitamin D (VitD) and insulin-like growth factor (IGF)-1 and their mutual relationship …

Excess lipid accumulation resulting from an elevated supply of plasma fatty acids is linked to
the pathogenesis of the metabolic syndrome and heart disease. The term 'lipotoxicity'was …

The decline in muscle function is associated with an age-related decrease in muscle mass
and an age-related decline in strength. However, decreased strength is not solely due to …

Skeletal muscle utilizes both free fatty acids (FFAs) and glucose that circulate in the blood
stream. When blood glucose levels acutely increase, insulin stimulates muscle glucose …

Diets enriched with advanced glycation end products (AGE) have recently been related to
muscle dysfunction processes. However, it remains unclear whether long-term exposure to …

Background Lipid hydroperoxides (LOOH) have been implicated in skeletal muscle atrophy
with age and disuse. Lysophosphatidylcholine acyltransferase 3 (LPCAT3), an enzyme of …

Shifts in myosin heavy chain (MHC) expression within skeletal muscle can be induced by a
host of stimuli including, but not limited to, physical activity, alterations in neural activity …

One of the hallmarks of ageing is muscle wasting that may be preceded by morphological
changes, such as capillary rarefaction. Muscle-specific changes in morphology in early …

The purpose of this work was to determine the effect of early‐onset calorie restriction on
sarcopenia in the aging rat. Ad libitum (AL) fed animals were examined at 5, 18, 21, and 36 …

Increase in fat mass (FM) and changes in body composition may account for the age-
associated impairment in insulin action on muscle glycogen storage. We wish to examine …