Fasting in human subjects shifts skeletal muscle metabolism toward lipid utilization and
accumulation, including intramyocellular lipid (IMCL) deposition. Growth hormone (GH) …

In lean humans, increasing dietary fat intake causes an increase in whole-body fat oxidation
and changes in genes that regulate fat oxidation in skeletal muscle, but whether this occurs …

The aim of the present study was to identify the genes differentially expressed in the visceral
adipose tissue in a well-characterised mouse model of high-fat diet (HFD)-induced obesity …

The purpose of the present study was to examine the utilization of fatty acids (FA) and
muscle substrates by skeletal muscle in young, middle-aged, and old adult rats under …

Obesity and ensuing disorders are increasingly prevalent worldwide. High-fat diets (HFD)
and diet-induced obesity have been shown to induce oxidative stress and inflammation …

Background Type 2 diabetes mellitus and muscle insulin resistance have been associated
with reduced capacity of skeletal muscle mitochondria, possibly as a result of increased …

Chronic mild stress (CMS) has been often associated to the pathogenesis of many diseases
including obesity. Indeed, visceral obesity has been linked to the development of metabolic …

Obesity and aging are characterized by decreased insulin sensitivity (IS) and muscle protein
synthesis. Intramuscular ceramide accumulation has been implicated in insulin resistance …

Restriction of a high-fat diet (HFD) and a change to a low-fat diet (LFD) are two interventions
that were shown to promote weight loss and improve parameters of metabolic health in …

Obesity-induced lipid oversupply promotes skeletal muscle mitochondrial biogenesis.
Previous investigations have utilized extreme high-fat diets (HFD) to induce such …