BACKGROUND: In several human cancers, overexpression of Skp2 (S-phase kinase
associated protein 2), which targets p27 for degradation, portends a poorer prognosis. We …

The F-box protein Skp2 (Fbl1) is a positive regulator of G1-S transition and promotes
ubiquitin-mediated proteolysis of the cyclin-dependent kinase inhibitor p27. Its …

Purpose: The purpose is to investigate the clinical relevance of altered patterns of p27 and
Skp2 expression in African-American patients with localized prostate cancer. The …

Purpose: Prostate carcinomas show a low level of the cell cycle inhibitor p27, which
correlates with tumor aggressiveness. In tumors p27 is of the WT species and its …

OBJECTIVES: To analyze p27 and S-phase kinase-associated protein 2 (Skp2) expression
in upper urinary tract transitional cell carcinoma (TCC) with respect to biologic significance …

Methods Skp2 and p27 (kip1) protein expression were evaluated in the tissues of 41 human
prostatic carcinomas as well as 20 benign prostatic hyperplasia (BPH) using …

We have demonstrated that phenylacetate (PA)-induced cell cycle arrest in human prostate
cancer is mediated by increase of p27. In this study, we further investigated the mechanism …

BACKGROUND The intervention of advanced prostate cancer (PCa) in patients has been
commonly depending on androgen deprivation therapy. Despite of tremendous research …

Skp2 is a crucial component of SCFSkp2 E3 ubiquitin ligase and is often overexpressed in
various types of cancer, including prostate cancer (PCa). The epithelial-to-mesenchymal …

Low or absent expression of the cyclin-dependent kinase inhibitor p27Kip1 serves as an
excellent malignant marker for prostate and other human cancers. The level of p27Kip1 is …