Intracranial hypertension is caused by brain edema generated by different disorders, the
commonest of which is traumatic brain injury. The treatment of brain edema focuses on …

Abstract Purpose of Review: Hyperosmolar therapy is one of the core medical treatments for
brain edema and intracranial hypertension, but controversy exists regarding the use of the …

Increased intracranial pressure after neurologic injury is a clinical challenge that often
requires administration of osmotic agents. The most common osmotic agent used for …

Mannitol has long been the “gold standard” for treatment of cerebral edema and refractory
intracranial hypertension in traumatic brain injury, subarachnoid hemorrhage, and stroke …

Abstract Purpose of the Review The aims of fluid management in acute brain injury are to
preserve or restore physiology and guarantee appropriate tissue perfusion, avoiding …

Background Osmotherapy has been the cornerstone in the management of patients with
elevated intracranial pressure (ICP) following traumatic brain injury (TBI). Several studies …

Cerebral edema is a significant cause of elevated intracranial pressure and a consequence
of secondary injury following traumatic brain injury. The use of hyperosmolar agents has …

Hyperosmolar therapy is regarded as the mainstay for treatment of elevated intracranial
pressure (ICP) in traumatic brain injury (TBI). This still has been disputed as application of …

Background: Mannitol and hypertonic saline (HTS) are effective in reducing intracranial
pressure (ICP) after severe traumatic brain injury (TBI). However, their efficacy on the ICP …

Object The purpose of this study was to compare the effects of mannitol and hypertonic
saline in doses of similar osmotic burden for the treatment of intracranial hypertension in …