FISH identifies a KAT6A/CREBBP fusion caused by a cryptic insertional t (8; 16) in a case of spontaneously remitting congenital acute myeloid leukemia with a normal …

R Barrett, B Morash, D Roback… - Pediatric Blood & …, 2017 - Wiley Online Library
Cytogenetics can inform risk stratification in pediatric acute myeloid leukemia (AML). We
describe the first case of a newborn with leukemia cutis found to have AML harboring a …

The translocation t (1; 22)(p13; q13) is a nonrandom marker specifically associated with acute megakaryocytic leukemia in young children

T Lion, OA Haas, J Harbott, E Bannier, J Ritterbach… - 1992 - ashpublications.org
We present the nonrandom occurrence, frequency, and degree of immunophenotype
association of the t (1; 22)(p13; q13) in children with acute nonlymphocytic leukemia (ANLL) …

Identification of a novel KMT2A/GIMAP8 gene fusion in a pediatric patient with acute undifferentiated leukemia

HE Berg, PR Blackburn, LB Baughn… - Genes …, 2021 - Wiley Online Library
Acute undifferentiated leukemia (AUL) is a very rare hematologic neoplasm that expresses
no markers specific for either myeloid or lymphoid lineages. While commonly observed in …

Cryptic and atypical KMT2A‐USP2 and KMT2A‐USP8 rearrangements identified by mate pair sequencing in infant and childhood leukemia

PR Blackburn, JB Smadbeck, I Znoyko… - Genes …, 2020 - Wiley Online Library
Infant leukemias are a rare group of neoplasms that are clinically and biologically distinct
from their pediatric and adult counterparts. Unlike leukemia in older children where survival …

Distinctive flow cytometric and mutational profile of acute myeloid leukemia with t (8; 16)(p11; p13) translocation

B Aqil, J Gao, M Stalling, M Sukhanova… - American journal of …, 2022 - academic.oup.com
Objectives Acute myeloid leukemia (AML) with t (8; 16)(p11; p13) abnormalities is a rare,
aggressive, and diagnostically challenging subtype that results in KAT6A-CREBBP gene …

[HTML][HTML] Crebbp alterations are associated with a poor prognosis in de novo AML

AJ Lamble, RB Gerbing, JL Smith, RE Ries, EA Kolb… - Blood, 2021 - Elsevier
Abstract Introduction: The translocation, t (8; 16)(p11; p13), results in the fusion between
KAT6A and CREBBP and has been associated with a poor prognosis in both pediatric and …

Acute myeloid leukemia with t (10; 11)(p11‐12; q23. 3): Results of Russian Pediatric AML registration study

E Zerkalenkova, S Lebedeva… - … journal of laboratory …, 2019 - Wiley Online Library
Introduction Translocations involving the KMT2A gene (also known as MLL) are frequently
diagnosed in pediatric acute leukemia cases with either lymphoblastic or myeloid origin …

Translocation (10; 11)(p12; q23) in childhood acute myeloid leukemia: incidence and complex mechanism

I Stasevich, R Utskevich, A Kustanovich… - Cancer genetics and …, 2006 - Elsevier
Using both conventional and molecular cytogenetic methods, we found five new cases of t
(10; 11)(p12; q23). This translocation represented 28% of all cases of childhood AML treated …

Acute myeloid leukemia with t(8;16)(p11.2;p13.3)/KAT6A-CREBBP in adults

W Xie, S Hu, J Xu, Z Chen, LJ Medeiros, G Tang - Annals of hematology, 2019 - Springer
Abstract t (8; 16)(p11. 2; p13. 3)/KAT6A-CREBBP is a rare recurrent cytogenetic abnormality
associated with acute myeloid leukemia (AML). We report 15 cases with t (8; 16)(p11. 2; p13 …

Revised risk stratification criteria for children with newly diagnosed acute myeloid leukemia: a report from the Children's Oncology Group

TM Cooper, RE Ries, TA Alonzo, RB Gerbing… - Blood, 2017 - ashpublications.org
Introduction: Currently, most phenotypic, cytogenetic or molecular markers identified in
children with acute myeloid leukemia (AML) are not used for risk stratification or treatment …