Abstract Background PI3K-Akt pathway activation and the expression of histone
deacetylases (HDACs) are highly increased in esophageal cancer, suggesting that …

Background Protein neddylation plays a tumor-promoting role in esophageal cancer. Our
previous study demonstrated that neddylation inhibition induced the accumulation of ATF4 …

The effect and regulation of autophagy-related proteins Beclin-1 and LC3 in esophageal
squamous cell carcinoma have not been fully studied. The aim of this study was to assess …

As the activation of autophagy contributes to the efficacy of many anticancer therapies,
deciphering the precise role of autophagy in cancer therapy is critical. Here, we report that …

The EGFR (epidermal growth factor receptor) signaling pathway is frequently deregulated in
many malignancies. Therefore, targeting the EGFR pathway is regarded as a promising …

The neddylation pathway is overactivated in esophageal cancer. Our previous studies
indicated that inactivation of neddylation by the NAE inhibitor induced apoptosis and …

Background Apatinib, a novel vascular endothelial growth factor receptor-2 (VEGFR-2)
tyrosine kinase inhibitor, has been approved for the treatment of metastatic gastric cancer …

Gastric cancer represents a significant global health concern, necessitating the exploration
of novel therapeutic options. Diosmetin, a natural flavonoid derived from citrus and …

Modulation of autophagy has been increasingly regarded as a promising cancer therapeutic
approach. In this study, we screened several ginsenosides extracted from Panax ginseng …

There are numerous studies that demonstrate the anti-neoplastic activity of
phosphatidylinositol 3-kinase (PI3K) inhibitors and the mechanisms of inducing autophagy …