Reduced expression and activity of the proapoptotic, double-stranded RNA-dependent
protein kinase, PKR (protein kinase R) is observed in breast, lung and various leukemias …

The double‐stranded RNA‐dependent kinase PKR has been described for many years as
strictly a pro‐apoptotic kinase. Recent data suggest that the main purpose of this kinase is …

Protein kinase R (PKR) is an interferon (IFN)-inducible, double-stranded RNA-activated
kinase that initiates apoptosis in response to cellular stress. To determine the role of PKR in …

Protein phosphatase 2A (PP2A) is a heterotrimer comprising catalytic, scaffold, and
regulatory (B) subunits. There are at least 21 B subunit family members. Thus PP2A is …

Recent reports demonstrate that PKR is constitutively active in a variety of tumors and is
required for tumor maintenance and growth. Here we report acute leukemia cell lines …

Deregulated activity of the BCR-ABL tyrosine kinase encoded by the Bcr-Abl oncogene
represents an important therapeutic target for all the chronic myelogenous leukemia (CML) …

Increased expression of the interferon-inducible double-stranded RNA-activated protein
kinase (PKR) has been reported in acute leukemia and solid tumors, but the role of PKR has …

Gain of functional mutations in ras occurs in more than 30% of human malignancies and in
particular 90% of pancreatic cancer. Mutant ras, via activating multiple effector pathways, not …

Future Oncol.(2010) 6 (5) 644 future science group to various forms of DNA damage [13, 14].
By doing so, PKR conveys a cytoprotective effect by inducing a G0/G1 arrest as a result of …

RNA-dependent protein kinase is an interferon-induced, double-stranded (ds), RNA-
activated serine/threonine protein kinase involved in the eukaryotic response to viral …