Inflammation is considered a response set by the tissues in response to injury elicited by
trauma or infection. It is a complex network of molecular and cellular interactions that …

Ageing is an inexorable intrinsic process that affects all cells, tissues, organs and
individuals. Due to a diminished homeostasis and increased organism frailty, ageing causes …

The aging process is driven by multiple mechanisms that lead to changes in energy
production, oxidative stress, homeostatic dysregulation and eventually to loss of functionality …

A typical feature of ageing is a chronic, low-grade inflammation characterized by a general
increase in the production of proinflammatory cytokines and inflammatory markers (“inflamm …

Cancer is generally recognized as an age-related disease. In fact, incidence and mortality
rates of most human cancers increase consistently with age up to 90 years, but they plateau …

The process of maintaining life for the individual is a constant struggle to preserve his/her
integrity. This can come at a price when immunity is involved, namely systemic inflammation …

Longevity and aging are two sides of the same coin, as they both derive from the interaction
between genetic and environmental factors. Aging is a complex, dynamic biological process …

Nowadays, people are living much longer than they used to do, however they are not free
from ageing. Ageing, an inexorable intrinsic process that affects all cells, tissues, organs and …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

For over 10 years we have studied centenarians as a model to address the biological basis
of aging and longevity, with particular attention to immunology and genetics. The most …