Gamma-aminobutyric acid transporters in the nucleus tractus solitarii regulate inhibitory and excitatory synaptic currents that influence cardiorespiratory function

D Martinez, L Lima-Silveira, MP Matott… - Frontiers in …, 2022 - frontiersin.org
The brainstem nucleus tractus solitarii (nTS) processes and modulates the afferent arc of
critical peripheral cardiorespiratory reflexes. Sensory afferents release glutamate to initiate …

The role of astrocytes in the nucleus tractus solitarii in maintaining central control of autonomic function

D Martinez, DD Kline - American Journal of Physiology …, 2021 - journals.physiology.org
The nucleus tractus solitarii (nTS) is the first central site for the termination and integration of
autonomic and respiratory sensory information. Sensory afferents terminating in the nTS as …

Excitatory amino acid transporters tonically restrain nTS synaptic and neuronal activity to modulate cardiorespiratory function

MP Matott, BC Ruyle, EM Hasser… - Journal of …, 2016 - journals.physiology.org
The nucleus tractus solitarii (nTS) is the initial central termination site for visceral afferents
and is important for modulation and integration of multiple reflexes including …

Glial EAAT2 regulation of extracellular nTS glutamate critically controls neuronal activity and cardiorespiratory reflexes

MP Matott, DD Kline, EM Hasser - The Journal of physiology, 2017 - Wiley Online Library
Key points Excitatory amino acid transporter 2 (EAAT2) is present on astrocytes in the
nucleus tractus solitarii (nTS), an important nucleus in cardiorespiratory control. Its specific …

Role of GABAergic neurones in the nucleus tractus solitarii in modulation of cardiovascular activity

J Zubcevic, JT Potts - Experimental physiology, 2010 - Wiley Online Library
GABAergic neurones are interspersed throughout the nucleus tractus solitarii (NTS), and
their tonic activity is crucial to the maintenance of cardiorespiratory homeostasis. However …

Depressed GABA and glutamate synaptic signaling by 5-HT1A receptors in the nucleus tractus solitarii and their role in cardiorespiratory function

TD Ostrowski, D Ostrowski… - Journal of …, 2014 - journals.physiology.org
Serotonin (5-HT), and its 5-HT1A receptor (5-HT1AR) subtype, is a powerful modulator of the
cardiorespiratory system and its sensory reflexes. The nucleus tractus solitarii (nTS) serves …

Astrocytic glutamate transporters reduce the neuronal and physiological influence of metabotropic glutamate receptors in nucleus tractus solitarii

D Martinez, RC Rogers, GE Hermann… - American Journal …, 2020 - journals.physiology.org
Astrocytic excitatory amino acid transporters (EAATs) are critical to restraining synaptic and
neuronal activity in the nucleus tractus solitarii (nTS). Relief of nTS EAAT restraint generates …

Vagotomy blunts cardiorespiratory responses to vagal afferent stimulation via pre‐and postsynaptic effects in the nucleus tractus solitarii

GC Hofmann, P Gama de Barcellos Filho… - The Journal of …, 2024 - Wiley Online Library
Viscerosensory information travels to the brain via vagal afferents, where it is first integrated
within the brainstem nucleus tractus solitarii (nTS), a critical contributor to cardiorespiratory …

Cardiovascular deconditioning increases GABA signaling in the nucleus tractus solitarii

L Lima-Silveira, EM Hasser… - Journal of …, 2022 - journals.physiology.org
The nucleus tractus solitarii (nTS) is the major integrative brainstem region for autonomic
modulation and processing of cardiovascular reflexes. GABA and glutamate are the main …

Glutamate suppresses GABA release via presynaptic metabotropic glutamate receptors at baroreceptor neurones in rats

CY Chen, AC Bonham - The Journal of physiology, 2005 - Wiley Online Library
The nucleus tractus solitarii (NTS) is essential for coordinating arterial baroreflex control of
blood pressure. The primary baroreceptor afferent fibres make their first excitatory synaptic …