The cadherins are a family of adhesive proteins involved in cell-cell homophilic interactions.
VE-cadherin, expressed in endothelial cells, is involved in morphogenesis, regulation of …

VE-cadherin was first identified in the early 1990s and quickly emerged as an important
endothelial cell adhesion molecule. The past decade of research has revealed key roles for …

Vascular endothelial cadherin (VE-cadherin, cadherin-5, or 7B4) is an endothelial specific
cadherin that regulates cell to cell junction organization in this cell type. Cadherin linkage to …

The mechanisms by which catenins regulate cadherin function are not fully understood, and
the precise function of p120 catenin (p120ctn) has remained particularly elusive. In …

E-and P-cadherin are members of a family of calcium-dependent, cell surface glycoproteins
involved in cell-cell adhesion. Extracellularly, the transmembrane cadherins self-associate …

Cadherins are transmembrane glycoproteins involved in Ca 2+-dependent cell-cell
adhesion. Previously, we showed that the conserved membrane-proximal region of the E …

p120ctn is a catenin whose direct binding to the juxtamembrane domain of classical
cadherins suggests a role in regulating cell–cell adhesion. The juxtamembrane domain has …

Cadherin cell–cell adhesion molecules form membrane-spanning molecular complexes that
couple homophilic binding by the cadherin ectodomain to the actin cytoskeleton. A …

Classical cadherins associate with three cytoplasmic proteins, termed α,-β-and γ-catenin.
This association mediates the attachment of cadherins to the microfilament network, which is …

Cadherins are calcium-dependent glycoproteins that function as cell-cell adhesion
molecules and are linked to the actin cytoskeleton via catenins. Newly synthesized …